Mihatsch M J, Steiner K, Abeywickrama K H, Landmann J, Thiel G
Department of Pathology, University Basel, Switzerland.
Clin Nephrol. 1988 Apr;29(4):165-75.
Ninety CSA-treated kidney transplants recipients entered the study. The patients were allocated to three groups based on serum creatinine at 12 months and kidney biopsy findings: control group (serum creatinine less than 177 mumol/l), rejection group (verified by biopsy, serum creatinine greater than 177 mumol/l), nephrotoxicity group (verified by biopsy, serum creatinine greater than 177 mumol/l). Thirty variables were systematically evaluated. The following parameters had a predictive value for the development of chronic CSA-nephrotoxicity: number of CSA-induced episodes of acute deterioration of renal function, CSA trough level (day 0-30, day 31-90), number of unexplained episodes of acute deterioration of renal function, number of nephrotoxic drugs, number of rejection treatments, number of rejection episodes and primary poor renal function. The results indicate that all factors leading to acute renal failure, favor the development of CSA-nephrotoxicity.
90名接受环孢素A（CSA）治疗的肾移植受者进入该研究。根据12个月时的血清肌酐水平和肾活检结果，将患者分为三组：对照组（血清肌酐低于177微摩尔/升）、排斥组（经活检证实，血清肌酐高于177微摩尔/升）、肾毒性组（经活检证实，血清肌酐高于177微摩尔/升）。系统评估了30个变量。以下参数对慢性CSA肾毒性的发生具有预测价值：CSA诱导的肾功能急性恶化发作次数、CSA谷浓度（第0 - 30天、第31 - 90天）、不明原因的肾功能急性恶化发作次数、肾毒性药物数量、排斥治疗次数、排斥发作次数以及原发性肾功能不佳。结果表明，所有导致急性肾衰竭的因素都有利于CSA肾毒性的发生。
