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1
Repair of single base-pair transversion mismatches of Escherichia coli in vitro: correction of certain A/G mismatches is independent of dam methylation and host mutHLS gene functions.体外修复大肠杆菌单碱基对颠换错配：某些A/G错配的校正独立于dam甲基化和宿主mutHLS基因功能。
Genetics. 1988 Apr;118(4):593-600. doi: 10.1093/genetics/118.4.593.
2
Mispair specificity of methyl-directed DNA mismatch correction in vitro.体外甲基化导向的DNA错配修复的错配特异性
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3
Methyl-directed mismatch repair is bidirectional.甲基化导向的错配修复是双向的。
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4
Processing of mispaired and unpaired bases in heteroduplex DNA in E. coli.大肠杆菌中异源双链DNA错配和未配对碱基的处理
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Methyl-directed repair of DNA base-pair mismatches in vitro.体外甲基化指导的DNA碱基对错配修复
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本文引用的文献

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Repair of defined single base-pair mismatches in Escherichia coli.大肠杆菌中定义的单个碱基对错配的修复。
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2
Escherichia coli dam methylase. Physical and catalytic properties of the homogeneous enzyme.大肠杆菌DNA腺嘌呤甲基化酶。纯酶的物理性质和催化特性。
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Asymmetric repair of bacteriophage T7 heteroduplex DNA.噬菌体T7异源双链DNA的不对称修复
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Different base/base mismatches are corrected with different efficiencies by the methyl-directed DNA mismatch-repair system of E. coli.大肠杆菌的甲基化导向DNA错配修复系统对不同的碱基/碱基错配进行校正的效率不同。
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Mismatch repair in Streptococcus pneumoniae: relationship between base mismatches and transformation efficiencies.肺炎链球菌中的错配修复：碱基错配与转化效率之间的关系。
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Methyl-directed repair of DNA base-pair mismatches in vitro.体外甲基化指导的DNA碱基对错配修复
Proc Natl Acad Sci U S A. 1983 Aug;80(15):4639-43. doi: 10.1073/pnas.80.15.4639.
8
Identification of base mismatches recognized by the heteroduplex-DNA-repair system of Streptococcus pneumoniae.肺炎链球菌异源双链DNA修复系统识别的碱基错配鉴定。
Cell. 1982 Dec;31(2 Pt 1):327-36. doi: 10.1016/0092-8674(82)90126-x.
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Base specificity of mismatch repair in Streptococcus pneumoniae.肺炎链球菌错配修复的碱基特异性
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体外修复大肠杆菌单碱基对颠换错配：某些A/G错配的校正独立于dam甲基化和宿主mutHLS基因功能。

Repair of single base-pair transversion mismatches of Escherichia coli in vitro: correction of certain A/G mismatches is independent of dam methylation and host mutHLS gene functions.

作者信息

Lu A L, Chang D Y

机构信息

Department of Biological Chemistry, University of Maryland School of Medicine, Baltimore 21201.

出版信息

Genetics. 1988 Apr;118(4):593-600. doi: 10.1093/genetics/118.4.593.

DOI:10.1093/genetics/118.4.593
PMID:3284785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1203314/
Abstract

Six different base-pair transversion mismatches are repaired with different efficiencies in an in vitro mismatch repair system. In particular, the T/T and C/C mismatches appear to be less efficiently repaired than the A/A and G/G mismatches. Four A/G and four C/T mismatches at different positions are repaired to different extents. One of the A/G mismatches is repaired equally efficiently when DNA heteroduplexes are fully methylated or hemi-methylated at the d(GATC) sequences. This type of mismatch repair appears to be unidirectional with A to C conversion by acting at A/G mispairs to restore the C/G pairs. This methylation-independent correction is not controlled by the mutH, mutL, mutS, uvrE, uvrB, phr, recA, recF, and recJ gene products. The independence of the transversion mismatch repair of these genes and methylation distinguishes this from the known mismatch repair pathways.

摘要

在体外错配修复系统中，六种不同的碱基对颠换错配以不同的效率被修复。具体而言，T/T和C/C错配的修复效率似乎低于A/A和G/G错配。不同位置的四个A/G和四个C/T错配被修复的程度不同。当DNA异源双链在d(GATC)序列处完全甲基化或半甲基化时，其中一个A/G错配的修复效率相同。这种错配修复似乎是单向的，通过作用于A/G错配将A转换为C以恢复C/G对。这种不依赖甲基化的校正不受mutH、mutL、mutS、uvrE、uvrB、phr、recA、recF和recJ基因产物的控制。这些基因和甲基化在颠换错配修复中的独立性使其有别于已知的错配修复途径。