Cilmiaty Risya, Pribadi Nirawati, Rukmo Mandojo, Surboyo Meircurius Dwi Condro
Department of Oral Disease, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia.
Department of Conservative Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Clin Cosmet Investig Dent. 2020 Aug 5;12:313-318. doi: 10.2147/CCIDE.S256284. eCollection 2020.
Endodontic treatment on dental caries with dental granuloma on the periapical has the potential to flare. The symptoms of acute flare in dental granuloma are strongly related to the activation of macrophages that produce pro-inflammatory cytokine through nuclear factor kappa B (NFκB). However, the role of NFκB in dental granuloma has not been widely explained.
To compare NFκB expression in dental granuloma and dental nongranuloma in the periapical of dental caries.
The periapical lesion of dental granuloma and dental nongranuloma was obtained from patients with dental caries who were subjected to tooth extraction. The periapical lesion was confirmed by periapical radiography and then differentiated by histological and immunohistochemistry by analyzing the NFκB expression.
Most dental granulomas were found in females (66.67%) between the ages 36 and 45 (61.11%). Dental granuloma showed higher NFκB expression compared to dental nongranuloma lesions in tooth caries (p=0.021).
The dental granuloma tissue of dental caries showed an increase in NFκB expression. Understanding the role of NFκB might provide additional insights into the process of periapical lesion development.
对伴有根尖牙肉芽肿的龋齿进行根管治疗有引发炎症加剧的可能性。牙肉芽肿急性炎症加剧的症状与巨噬细胞的激活密切相关，巨噬细胞通过核因子κB（NFκB）产生促炎细胞因子。然而，NFκB在牙肉芽肿中的作用尚未得到广泛阐释。
比较龋齿根尖牙肉芽肿与非牙肉芽肿中NFκB的表达情况。
从接受拔牙治疗的龋齿患者中获取根尖牙肉芽肿和非牙肉芽肿的根尖病变组织。通过根尖X线片确认根尖病变，然后通过组织学和免疫组织化学分析NFκB表达来进行鉴别。
大多数牙肉芽肿见于36至45岁的女性（61.11%），占女性患者的66.67%。与龋齿中的非牙肉芽肿病变相比，牙肉芽肿显示出更高的NFκB表达（p=0.021）。
龋齿的牙肉芽肿组织中NFκB表达增加。了解NFκB的作用可能为根尖病变发展过程提供更多见解。
