Davoodi Poorandokht, Hamian Mina, Nourbaksh Reza, Ahmadi Motamayel Fatemeh
Assistant Professor, Department of Oral Medicine, Dental School, Hamadan University of Medical Sciences, Hamadan, Iran.
J Dent Res Dent Clin Dent Prospects. 2010 Fall;4(4):115-9. doi: 10.5681/joddd.2010.029. Epub 2010 Dec 21.
The onset of opportunistic infections in HIV-positive patients is generally associated with a low CD4 count. Oral manifestations can be the first clinical sign of the infection and also determine the progression of disease. The purpose of this study was to determine the prevalence of oral soft tissue manifestations and their relationship with the degree of immunosuppression observed in HIV-positive patients.
100 HIV-positive patients were examined. Oral lesions were evaluated according to EEC clearing house criteria. The degree of immunosuppression was based on the CD4 count closest to the oral examination. Data were analyzed using Student's t-test and chi-square test.
The most common oral lesions were rampant caries (54%), periodontal disease (44%), and hyperpigmentation (42%). Salivary glands enlargements and leukoplakia were associated with more severe immunosuppression.
According to the results, it seems that occurrence of only some of oral lesions are related to the degree of immunosuppression and such lesions can be considered as indicators of the progression of the HIV infection.
HIV 阳性患者机会性感染的发生通常与 CD4 细胞计数低有关。口腔表现可能是感染的首个临床症状，也决定着疾病的进展。本研究的目的是确定 HIV 阳性患者口腔软组织表现的患病率及其与观察到的免疫抑制程度的关系。
对 100 名 HIV 阳性患者进行了检查。根据欧洲经济共同体信息交换所标准对口腔病变进行评估。免疫抑制程度基于最接近口腔检查时的 CD4 细胞计数。使用学生 t 检验和卡方检验对数据进行分析。
最常见的口腔病变是猖獗龋（54%）、牙周病（44%）和色素沉着（42%）。唾液腺肿大和白斑与更严重的免疫抑制有关。
根据结果，似乎只有部分口腔病变的发生与免疫抑制程度有关，此类病变可被视为 HIV 感染进展的指标。
