Heng Boon C, Zhang Xuehui, Aubel Dominique, Bai Yunyang, Li Xiaochan, Wei Yan, Fussenegger Martin, Deng Xuliang
Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China.
Faculty of Science and Technology, Sunway University, Subang Jaya, Malaysia.
Front Cell Dev Biol. 2020 Jul 30;8:735. doi: 10.3389/fcell.2020.00735. eCollection 2020.
The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional co-activator proteins that play key roles in many diverse biological processes, ranging from cell proliferation, tumorigenesis, mechanosensing and cell lineage fate determination, to wound healing and regeneration. In this review, we discuss the regulatory mechanisms by which YAP/TAZ control stem/progenitor cell differentiation into the various major lineages that are of interest to tissue engineering and regenerative medicine applications. Of particular interest is the key role of YAP/TAZ in maintaining the delicate balance between quiescence, self-renewal, proliferation and differentiation of endogenous adult stem cells within various tissues/organs during early development, normal homeostasis and regeneration/healing. Finally, we will consider how increasing knowledge of YAP/TAZ signaling might influence the trajectory of future progress in regenerative medicine.
Hippo信号通路的倒数第二个效应因子YAP和TAZ是转录共激活蛋白，在许多不同的生物学过程中发挥关键作用，这些过程包括细胞增殖、肿瘤发生、机械传感和细胞谱系命运决定，以及伤口愈合和再生。在这篇综述中，我们讨论了YAP/TAZ控制干细胞/祖细胞分化为组织工程和再生医学应用中感兴趣的各种主要谱系的调控机制。特别值得关注的是，YAP/TAZ在早期发育、正常稳态以及再生/愈合过程中，维持各种组织/器官内源性成体干细胞在静止、自我更新、增殖和分化之间的微妙平衡方面所起的关键作用。最后，我们将探讨对YAP/TAZ信号通路认识的不断增加可能如何影响再生医学未来的发展轨迹。
