Tavallaee Ghazaleh, Rockel Jason S, Lively Starlee, Kapoor Mohit
Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Front Med (Lausanne). 2020 Aug 11;7:376. doi: 10.3389/fmed.2020.00376. eCollection 2020.
Osteoarthritis (OA) is the most common type of arthritis, a disease that affects the entire joint. The relative involvement of each tissue, and their interactions, add to the complexity of OA, hampering our understanding of the underlying molecular mechanisms, and the generation of a disease modifying therapy. The synovium is essential in maintaining joint homeostasis, and pathologies associated with the synovium contribute to joint destruction, pain and stiffness in OA. MicroRNAs (miRNAs) are post-transcriptional regulators dysregulated in OA tissues including the synovium. MiRNAs are important contributors to OA synovial changes that have the potential to improve our understanding of OA and to act as novel therapeutic targets. The purpose of this review is to summarize and integrate current published literature investigating the roles that miRNAs play in OA-related synovial pathologies including inflammation, matrix deposition and cell proliferation.
骨关节炎（OA）是最常见的关节炎类型，是一种影响整个关节的疾病。每个组织的相对参与及其相互作用增加了OA的复杂性，阻碍了我们对潜在分子机制的理解以及疾病修饰疗法的产生。滑膜对于维持关节稳态至关重要，与滑膜相关的病理变化会导致OA中的关节破坏、疼痛和僵硬。微小RNA（miRNA）是在包括滑膜在内的OA组织中失调的转录后调节因子。miRNA是OA滑膜变化的重要促成因素，有可能增进我们对OA的理解并充当新的治疗靶点。本综述的目的是总结和整合当前已发表的文献，这些文献研究了miRNA在与OA相关的滑膜病理（包括炎症、基质沉积和细胞增殖）中所起的作用。
