Department of Otolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100005, China.
Department of Otolaryngology, The First Affiliated Hospital of Xinjiang Medical University, Urumchi, 830011 Xinjiang Uygur Autonomous Region, China.
Biomed Res Int. 2020 Aug 10;2020:4178376. doi: 10.1155/2020/4178376. eCollection 2020.
To investigate whether preventive administration of a proton pump inhibitor (PPI) can reduce the occurrence and development of traumatic granuloma (TG) following type IV-VI cordectomy.
We retrospectively analyzed the status of postoperative granulomas in 37 patients who underwent type IV-VI cordectomy due to glottic cancer and determined whether postoperative administration of a PPI had any impact on granuloma formation and development.
The percentage and number of patients with granuloma in the PPI treatment group (experimental group) at the 1st, 2nd, 3rd, and 6th month following surgery were 81.25% (13/16), 25.00% (4/16), 18.75% (3/16), and 0.00% (0/16), respectively. The percentage and number of patients with granuloma in the no-PPI group (control group) were 95.24% (20/21), 71.43% (15/21), 52.38% (11/21), and 14.29% (3/21), respectively. The granuloma percentage of the PPI treatment group was lower than that of the control group at all postoperative time points assessed. The differences were not statistically significant at the 1st month ( = 0.175) but were statistically significant at the 2nd and 3rd months after surgery ( = 0.005, = 0.037).
Preventive use of a PPI in patients after type IV-VI cordectomy can shorten the TG recovery duration and may reduce the severity of TG, but it cannot prevent TG from occurring. Our results should be confirmed by prospective randomized controlled trials with large sample sizes.
探讨质子泵抑制剂（PPI）预防给药是否能减少 IV-VI 型声带切除术术后创伤性肉芽肿（TG）的发生和发展。
我们回顾性分析了 37 例因声门癌行 IV-VI 型声带切除术的患者术后肉芽肿的状况，并确定 PPI 术后给药是否对肉芽肿的形成和发展有影响。
PPI 治疗组（实验组）患者在术后第 1、2、3、6 个月的肉芽肿百分比和数量分别为 81.25%（13/16）、25.00%（4/16）、18.75%（3/16）和 0.00%（0/16）。无 PPI 组（对照组）患者的肉芽肿百分比和数量分别为 95.24%（20/21）、71.43%（15/21）、52.38%（11/21）和 14.29%（3/21）。实验组患者在所有术后评估时间点的肉芽肿百分比均低于对照组，第 1 个月的差异无统计学意义（ = 0.175），但在术后第 2 和第 3 个月的差异有统计学意义（ = 0.005， = 0.037）。
在 IV-VI 型声带切除术患者中预防性使用 PPI 可以缩短 TG 的恢复时间，并可能减轻 TG 的严重程度，但不能预防 TG 的发生。我们的结果需要通过大样本量的前瞻性随机对照试验来进一步证实。
