Reproductive Medicine Center, Yantai Yuhuangding Hospital, Yantai, China.
Gynecol Endocrinol. 2021 Apr;37(4):337-341. doi: 10.1080/09513590.2020.1812569. Epub 2020 Aug 27.
The effective treatment of polycystic ovary syndrome (PCOS)-related hormonal disorders necessitates the development of novel treatment strategies. Resveratrol is found in certain food products, and is known to exhibit phytoestrogen properties. The present study was to assess whether resveratrol exhibits beneficial phytoestrogenic effects and associated hormonal modulation in a rat model of PCOS.
This model was established by administering oral letrozole to female Sprague-Dawley (SD) rats prior to randomizing them into control, model and resveratrol treatment groups (40, 80, or 160 mg/kg). Animals were treated for 30 days, after which time ovarian tissues were collected and evaluated hematoxylin and eosin staining. In addition, serum levels of estradiol and adiponectin were assessed ELISA, and ovarian expression of nesfatin-1 and aromatase was assessed through RT-PCR and western blotting.
We found that resveratrol administration was associated with increased levels of plasma adiponectin and estradiol levels and restoration of normal ovarian morphology in PCOS model animals. In addition, this treatment was linked to the increased ovarian expression of nesfatin-1 and aromatase at the RNA and protein levels.
Together things findings suggest that resveratrol may represent an effective tool for treating PCOS owing to its phytoestrogenic properties.
多囊卵巢综合征（PCOS）相关激素紊乱的有效治疗需要开发新的治疗策略。白藜芦醇存在于某些食品中，已知具有植物雌激素特性。本研究旨在评估白藜芦醇在 PCOS 大鼠模型中是否表现出有益的植物雌激素作用和相关的激素调节作用。
本模型通过在将雌性 Sprague-Dawley（SD）大鼠随机分为对照组、模型组和白藜芦醇治疗组（40、80 或 160mg/kg）之前给予口服来曲唑来建立。动物治疗 30 天后，收集卵巢组织并进行苏木精和伊红染色评估。此外，通过 ELISA 评估血清雌二醇和脂联素水平，通过 RT-PCR 和 Western blot 评估卵巢 nesfatin-1 和芳香化酶的表达。
我们发现，白藜芦醇给药与血浆脂联素和雌二醇水平升高以及 PCOS 模型动物正常卵巢形态的恢复有关。此外，这种治疗与卵巢 nesfatin-1 和芳香化酶的 RNA 和蛋白质水平表达增加有关。
这些发现表明，白藜芦醇可能因其植物雌激素特性而成为治疗 PCOS 的有效工具。
