Williams G M, Weisburger J H
American Health Foundation, Valhalla, NY 10595.
Mutat Res. 1988 May-Aug;205(1-4):79-90. doi: 10.1016/0165-1218(88)90011-0.
The assessment of the potential carcinogenicity of a chemical requires a systematic approach taking into account various types of data. Important information on the DNA reactivity and other genetic effects of chemicals can be obtained from a battery of cellular tests. A battery is described which includes DNA repair in hepatocytes, mutagenesis in Salmonella typhimurium, mutagenesis, chromosome alterations, and transformation in mammalian cells. The interpretation of findings in this battery for the identification of potential carcinogenicity of chemicals is discussed.
对一种化学物质潜在致癌性的评估需要一种系统的方法，同时考虑各种类型的数据。关于化学物质的DNA反应性和其他遗传效应的重要信息可以从一系列细胞试验中获得。本文描述了一个试验组合，其中包括肝细胞中的DNA修复、鼠伤寒沙门氏菌中的诱变、诱变、染色体改变以及哺乳动物细胞中的转化。本文还讨论了利用该试验组合中的结果来识别化学物质潜在致癌性的解读方法。
