氯丙嗪的致突变活性。
The mutagenic activity of chlorpromazine.
作者信息
Obaseiki-Ebor E E, Akerele J O
机构信息
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Nigeria.
出版信息
Mutat Res. 1988 May;208(1):33-8. doi: 10.1016/0165-7992(88)90017-6.
The mutagenic activity of chlorpromazine hydrochloride based on the Ames plate incorporation test and the modified fluctuation test in the presence and absence of liver microsomal enzyme (S9 fraction) and NADPH was determined. The results indicated that chlorpromazine required activation for mutagenic activity for the reversion of some of the tester bacterial strains from tryptophan and histidine dependence to independence respectively. The positive response of Escherichia coli WP2 trp, uvrA, E. coli WP2 trp (pKM101 and pAQ1) and Salmonella typhimurium his TA102 indicated that chlorpromazine mediates base-pair substitution and frame-shift mutagenesis.
基于埃姆斯平板掺入试验以及在有和没有肝微粒体酶（S9组分）和烟酰胺腺嘌呤二核苷酸磷酸（NADPH）存在的情况下进行的改良波动试验，测定了盐酸氯丙嗪的致突变活性。结果表明，氯丙嗪需要激活才能产生致突变活性，从而使一些受试菌株分别从依赖色氨酸和组氨酸转变为不依赖。大肠杆菌WP2 trp、uvrA、大肠杆菌WP2 trp（pKM101和pAQ1）以及鼠伤寒沙门氏菌his TA102的阳性反应表明，氯丙嗪介导碱基对置换和移码突变。
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