Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany; Institute for Immunology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Immunity. 2020 Sep 15;53(3):487-495. doi: 10.1016/j.immuni.2020.08.003. Epub 2020 Aug 17.
Men present more frequently with severe manifestations of coronavirus disease 2019 (COVID-19) and are at higher risk for death. The underlying mechanisms for these differences between female and male individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are insufficiently understood. However, studies from other viral infections have shown that females can mount stronger immune responses against viruses than males. Emerging knowledge on the basic biological pathways that underlie differences in immune responses between women and men needs to be incorporated into research efforts on SARS-CoV-2 pathogenesis and pathology to identify targets for therapeutic interventions aimed at enhancing antiviral immune function and lung airway resilience while reducing pathogenic inflammation in COVID-19.
男性在感染严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）后更常出现严重的 2019 冠状病毒病（COVID-19）症状表现，并且死亡风险更高。对于女性和男性个体之间的这些差异，其潜在机制尚未得到充分理解。然而，来自其他病毒感染的研究表明，女性对病毒产生的免疫反应可能比男性更强。对于女性和男性之间免疫反应差异的基本生物学途径的新兴知识需要纳入 SARS-CoV-2 发病机制和病理学的研究工作中，以确定治疗干预的目标，旨在增强抗病毒免疫功能和肺气道弹性，同时减少 COVID-19 的致病性炎症。
