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纤维肌痛患者自杀行为的发生率。

The Prevalence of Suicidal Behaviour in Fibromyalgia Patients.

机构信息

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jun 8;108:110078. doi: 10.1016/j.pnpbp.2020.110078. Epub 2020 Aug 24.

Abstract

OBJECTIVE

Fibromyalgia (FM) is a condition associated with chronic pain in muscles and soft tissues. Extant literature has demonstrated an association between FM, mood symptoms and suicidal behaviour. This systematic review aims to synthesize available literature assessing the prevalence of suicidality in FM populations and qualitatively review the included articles.

METHODS

PsycINFO, Google Scholar and PubMed databases were systematically searched for studies published from database inception to 15 February 2020. Studies were included that assessed FM as a primary or co-primary disease condition, as well as an assessment of suicidal behaviour (suicidal ideations (SI), suicide attempts (SA) and death by suicide (SC)). The quality of the studies was assessed using the Newcastle-Ottawa Scale.

RESULTS

699 unique articles were reviewed for eligibility. Data were derived from nine studies (cross-sectional: k = 5; retrospective cohort: k = 4) that assessed suicidal behaviour in FM participants (SI: k = 5, SC: k = 3, SA: k = 3). Four studies assessing SI found elevated rates of SI among FM participants. Three studies found elevated risk for SC and three studies found increased SA in FM participants relative to the general population. In two studies, this association was no longer significant after adjusting for depression and other psychiatric comorbidities.

CONCLUSION

Preliminary findings suggest that FM is associated with significantly higher risks for SI, SA and SC compared to the general population. There may be unique risk factors underlying suicidal behaviour in FM patients and the interaction between FM and other known risk factors (i.e., mental illness) require further investigation.

摘要

目的

纤维肌痛(FM)是一种与肌肉和软组织慢性疼痛相关的疾病。现有文献表明,FM 与情绪症状和自杀行为之间存在关联。本系统评价旨在综合现有文献评估 FM 人群自杀的发生率,并对纳入的文章进行定性评价。

方法

系统检索 PsycINFO、Google Scholar 和 PubMed 数据库,检索时间从数据库建立到 2020 年 2 月 15 日。纳入评估 FM 为原发性或主要疾病,并评估自杀行为(自杀意念(SI)、自杀企图(SA)和自杀死亡(SC))的研究。使用纽卡斯尔-渥太华量表评估研究质量。

结果

对 699 篇符合条件的文章进行了综述。数据来自 9 项研究(横断面研究:k=5;回顾性队列研究:k=4),评估了 FM 参与者的自杀行为(SI:k=5,SC:k=3,SA:k=3)。四项评估 SI 的研究发现 FM 参与者的 SI 发生率较高。三项研究发现 FM 参与者的 SC 风险增加,三项研究发现 FM 参与者的 SA 增加。在两项研究中,调整抑郁和其他精神共病后,这种相关性不再显著。

结论

初步研究结果表明,与普通人群相比,FM 与 SI、SA 和 SC 的风险显著增加相关。FM 患者自杀行为的潜在风险因素可能是独特的,FM 与其他已知风险因素(即精神疾病)之间的相互作用需要进一步研究。

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