Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China; The Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, Guangdong Medical University, Zhanjiang 524023, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang), Zhanjiang 524023, China.
Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China.
Biomed Pharmacother. 2020 Nov;131:110644. doi: 10.1016/j.biopha.2020.110644. Epub 2020 Aug 24.
3D printing is an emerging field that can be found in medicine, electronics, aviation and other fields. 3D printing, with its personalized and highly customized characteristics, has great potential in the pharmaceutical industry. We were interested in how 3D printing can be used in drug fields. To find out 3D printing's application in drug fields, we collected the literature by combining the keywords "3D printing"/"additive manufacturing" and "drug"/"tablet". We found that 3D printing technology has the following applications in medicine: firstly, it can print pills on demand according to the individual condition of the patient, making the dosage more suitable for each patient's own physical condition; secondly, it can print tablets with specific shape and structure to control the release rate; thirdly, it can precisely control the distribution of cells, extracellular matrix and biomaterials to build organs or organ-on-a-chip for drug testing; finally, it could print loose porous pills to reduce swallowing difficulties, or be used to make transdermal microneedle patches to reduce pain of patients.
3D 打印是一个新兴领域，可应用于医学、电子、航空等领域。3D 打印具有个性化和高度定制化的特点，在制药行业有很大的潜力。我们对 3D 打印如何应用于药物领域很感兴趣。为了了解 3D 打印在药物领域的应用，我们通过组合关键词“3D 打印”/“增材制造”和“药物”/“片剂”来收集文献。我们发现 3D 打印技术在医学中有以下应用：首先，可以根据患者的个体情况按需打印药丸，使剂量更适合每个患者自身的身体状况；其次，可以打印具有特定形状和结构的片剂来控制释放速度；第三，可以精确控制细胞、细胞外基质和生物材料的分布，构建用于药物测试的器官或器官芯片；最后，可以打印疏松多孔的药丸以减少吞咽困难，或者用于制作经皮微针贴片以减轻患者的疼痛。
