药物添加剂制造：复杂和个性化药物输送系统的新工具。
Pharmaceutical Additive Manufacturing: a Novel Tool for Complex and Personalized Drug Delivery Systems.
机构信息
Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, Mississippi, 38677, USA.
Pii Center for Pharmaceutical Technology, The University of Mississippi, University, Mississippi, 38677, USA.
出版信息
AAPS PharmSciTech. 2018 Nov;19(8):3388-3402. doi: 10.1208/s12249-018-1097-x. Epub 2018 Jun 25.
Inter-individual variability is always an issue when treating patients of different races, genders, ages, pharmacogenetics, and pharmacokinetic characteristics. However, the development of novel dosage forms is limited by the huge investments required for production line modifications and dosages diversity. Additive manufacturing (AM) or 3D printing can be a novel alternative solution for the development of controlled release dosages because it can produce personalized or unique dosage forms and more complex drug-release profiles. The primary objective of this manuscript is to review the 3D printing processes that have been used in the pharmaceutical area, including their general aspects, materials, and the operation of each AM technique. Advantages and shortcomings of the technologies are discussed with respect to practice and practical applications. Thus, this review will provide an overview and discussion on advanced pharmaceutical AM technologies, which can be used to produce unique controlled drug delivery systems and personalized dosages for the future of personalized medicine.
当治疗不同种族、性别、年龄、药物遗传学和药代动力学特征的患者时，个体间的变异性始终是一个问题。然而，新型剂型的开发受到生产线改造和剂量多样性所需的巨额投资的限制。增材制造（AM）或 3D 打印技术可以成为开发控释剂型的一种新颖替代解决方案，因为它可以生产个性化或独特的剂型和更复杂的药物释放曲线。本文的主要目的是综述已在制药领域中使用的 3D 打印工艺，包括其一般方面、材料以及每种 AM 技术的操作。讨论了这些技术在实践和实际应用中的优缺点。因此，本综述将提供对先进制药 AM 技术的概述和讨论，这些技术可用于生产独特的控释药物输送系统和个性化剂量，以满足个性化医疗的未来需求。
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