Lechin F, Van Der Dijs B, Bentolila A, Peña F
J Clin Pharmacol. 1977 Jul;17(7):431-40. doi: 10.1002/j.1552-4604.1977.tb04626.x.
Low doses of d-amphetamine plus propranolol rapidly improved the abdominal pain in 165 "spastic colon" patients. Concomitantly, these drugs reduced the sigmoidal hypertonicity and the rectal inhibition found in the manometric studies performed in some of those patients. The sigmoidal tone and phasic activity were also decreased by anticholinergic drugs. These results suggest that a cholinergic-serotonergic hyperactivity of the myenteric plexus may be responsible for the "spastic colon" syndrome.
低剂量的右旋苯丙胺加普萘洛尔能迅速改善165例“结肠痉挛”患者的腹痛症状。同时，这些药物降低了部分此类患者在测压研究中发现的乙状结肠高张力和直肠抑制。抗胆碱能药物也可降低乙状结肠张力和阶段性活动。这些结果表明，肌间神经丛的胆碱能-5-羟色胺能功能亢进可能是“结肠痉挛”综合征的病因。
