Department of Chemistry, University of California Davis, One Shields drive, Davis, CA 95616, USA.
Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, 2211 VM3B, Davis, CA 95616, USA.
Nutrients. 2020 Aug 25;12(9):2581. doi: 10.3390/nu12092581.
Alterations of transition metal levels have been associated with obesity, hepatic steatosis, and metabolic syndrome in humans. Studies in animals indicate an association between dietary sugars and copper metabolism. Our group has conducted a study in which young adults consumed beverages sweetened with glucose, fructose, high fructose corn syrup (HFCS), or aspartame for two weeks and has reported that consumption of both fructose- and HFCS-sweetened beverages increased cardiovascular disease risk factors. Baseline and intervention serum samples from 107 participants of this study were measured for copper metabolism (copper, ceruloplasmin ferroxidase activity, ceruloplasmin protein), zinc levels, and iron metabolism (iron, ferritin, and transferrin) parameters. Fructose and/or glucose consumption were associated with decreased ceruloplasmin ferroxidase activity and serum copper and zinc concentrations. Ceruloplasmin protein levels did not change in response to intervention. The changes in copper concentrations were correlated with zinc, but not with iron. The decreases in copper, ceruloplasmin ferroxidase activity, ferritin, and transferrin were inversely associated with the increases in metabolic risk factors associated with sugar consumption, specifically, apolipoprotein CIII, triglycerides, or post-meal glucose, insulin, and lactate responses. These findings are the first evidence that consumption of sugar-sweetened beverages can alter clinical parameters of transition metal metabolism in healthy subjects.
过渡金属水平的改变与人类肥胖、肝脂肪变性和代谢综合征有关。动物研究表明，饮食中的糖与铜代谢之间存在关联。我们的研究小组进行了一项研究，年轻成年人在两周内饮用用葡萄糖、果糖、高果糖玉米糖浆（HFCS）或阿斯巴甜加糖的饮料，研究报告表明，饮用果糖和 HFCS 加糖饮料都会增加心血管疾病的风险因素。本研究 107 名参与者的基线和干预血清样本用于测量铜代谢（铜、铜蓝蛋白氧化酶活性、铜蓝蛋白蛋白）、锌水平和铁代谢（铁、铁蛋白和转铁蛋白）参数。果糖和/或葡萄糖的消耗与铜蓝蛋白氧化酶活性以及血清铜和锌浓度降低有关。铜蓝蛋白蛋白水平对干预没有变化。铜浓度的变化与锌相关，但与铁无关。铜、铜蓝蛋白氧化酶活性、铁蛋白和转铁蛋白的减少与与糖消耗相关的代谢风险因素的增加呈负相关，具体为载脂蛋白 CIII、甘油三酯或餐后葡萄糖、胰岛素和乳酸反应。这些发现是首次证明饮用含糖饮料会改变健康受试者过渡金属代谢的临床参数。
