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2006 - 2010年美国军团病相关住院情况的趋势

Trends in Legionnaires' Disease-Associated Hospitalizations, United States, 2006-2010.

作者信息

Mudali Gayathri, Kilgore Paul E, Salim Abdulbaset, McElmurry Shawn P, Zervos Marcus

机构信息

Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan, USA.

Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.

出版信息

Open Forum Infect Dis. 2020 Jul 17;7(8):ofaa296. doi: 10.1093/ofid/ofaa296. eCollection 2020 Aug.

Abstract

BACKGROUND

is a waterborne cause of both healthcare-associated and community-acquired pneumonia. serogroup 1 is responsible for 80% of infections. There is currently limited published disease burden data on Legionnaires' disease-associated hospitalization in the United States.

METHODS

In this study, we estimated the annual incidence of Legionnaires' disease-associated hospitalizations in United States and identified demographic, temporal, and regional characteristics of individuals hospitalized for Legionnaires' disease. A retrospective study was conducted using the National Hospital Discharge Survey (NHDS) data from 2006 to 2010. The NHDS is a nationally representative US survey, which includes estimates of inpatient stays in short-stay hospitals in the United States, excluding federal, military, and Veterans Administration hospitals. All discharges assigned with the Legionnaires' disease discharge diagnostic code (482.84) were included in this study.

RESULTS

We observed the annual incidence and number of Legionnaires' disease-associated hospitalizations (per 100 000 population) in the United States by year, age, sex, race, and region. Over a 5-year period, 14 574 individuals experienced Legionnaires' disease-associated hospitalizations in the United States The annual population-adjusted incidence (per 100 000 population) of Legionnaires' disease-associated hospitalizations was 5.37 (95% confidence interval [CI], 5.12-5.64) in 2006, 7.06 (95% CI, 6.80-7.40) in 2007, 8.77 (95% CI, 8.44-9.11) in 2008, 17.07 (95% CI, 16.62-17.54) in 2009, and 9.66 (95% CI, 9.32-10.01) in 2010. A summer peak of Legionnaires' disease-associated hospitalizations occurred from June through September in 2006, 2007, 2008, and 2010.

CONCLUSIONS

Legionnaires' disease-associated hospitalizations significantly increased over the 5-year study period. The increasing disease burden of Legionnaires' disease suggests that large segments of the US population are at risk for exposure to this waterborne pathogen.

摘要

背景

是医疗保健相关肺炎和社区获得性肺炎的一种水源性病因。血清群1导致80%的感染。目前,美国关于军团病相关住院的已发表疾病负担数据有限。

方法

在本研究中,我们估计了美国军团病相关住院的年发病率,并确定了因军团病住院的个体的人口统计学、时间和区域特征。使用2006年至2010年的国家医院出院调查(NHDS)数据进行了一项回顾性研究。NHDS是一项具有全国代表性的美国调查,包括对美国短期住院医院住院时间的估计,不包括联邦、军事和退伍军人管理局医院。所有被分配军团病出院诊断代码(482.84)的出院病例都纳入了本研究。

结果

我们按年份、年龄、性别、种族和地区观察了美国军团病相关住院的年发病率和病例数(每10万人)。在5年期间,美国有14574人因军团病相关住院。2006年军团病相关住院的年人口调整发病率(每10万人)为5.37(95%置信区间[CI],5.12 - 5.64),2007年为7.06(95%CI,6.80 - 7.40),2008年为8.77(95%CI,8.44 - 9.11),2009年为17.07(95%CI,16.62 - 17.54),2010年为9.66(95%CI,9.32 - 10.01)。2006年、2007年、2008年和2010年,军团病相关住院在6月至9月出现夏季高峰。

结论

在5年的研究期间,军团病相关住院显著增加。军团病不断增加的疾病负担表明,美国很大一部分人口有接触这种水源性病原体的风险。

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