氨甲环酸用于急性胃肠道出血——一个警示故事。 - Suppr

Tranexamic acid in acute gastrointestinal bleeding - A cautionary tale.

作者信息

Roberts Lara N

机构信息

Department of Haematological Medicine, King's Thrombosis Centre, King's College Hospital NHS Foundation Trust, London, UK.

出版信息

J Thromb Haemost. 2020 Oct;18(10):2440-2443. doi: 10.1111/jth.15046. Epub 2020 Aug 28.

DOI:10.1111/jth.15046

PMID:32856769

Abstract

摘要

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Tranexamic acid in acute gastrointestinal bleeding - A cautionary tale.氨甲环酸用于急性胃肠道出血——一个警示故事。

J Thromb Haemost. 2020 Oct;18(10):2440-2443. doi: 10.1111/jth.15046. Epub 2020 Aug 28.

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial.高剂量 24 小时输注氨甲环酸对急性胃肠出血患者死亡和血栓栓塞事件的影响（HALT-IT）：一项国际随机、双盲、安慰剂对照试验。

Lancet. 2020 Jun 20;395(10241):1927-1936. doi: 10.1016/S0140-6736(20)30848-5.

Is tranexamic acid effective for acute upper gastrointestinal bleeding?氨甲环酸对急性上消化道出血有效吗？

Medwave. 2015 Dec 7;15 Suppl 3:e6330. doi: 10.5867/medwave.2015.6330.

[Tranexamic acid for upper gastrointestinal bleeding].[氨甲环酸用于上消化道出血]

Ugeskr Laeger. 2016 Apr 11;178(15):V09150773.

Tranexamic acid and Gastrointestinal bleed: Effect of the HALT-IT trial on current meta-analysis.氨甲环酸与胃肠道出血：HALT-IT试验对当前荟萃分析的影响。

Am J Emerg Med. 2022 Sep;59:165-167. doi: 10.1016/j.ajem.2022.06.050. Epub 2022 Jun 25.

HALT-IT--tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial.HALT-IT——氨甲环酸治疗胃肠道出血：一项随机对照试验的研究方案

Trials. 2014 Nov 19;15:450. doi: 10.1186/1745-6215-15-450.

Tranexamic acid should be avoided for acute gastrointestinal bleeds.氨甲环酸应避免用于急性胃肠道出血。

Drug Ther Bull. 2021 Jun;59(6):84. doi: 10.1136/dtb.2021.000016. Epub 2021 Mar 22.

Does tranexamic acid reduce 5-day death due to bleeding in acute gastrointestinal bleed?氨甲环酸能否降低急性胃肠道出血导致的5天内出血死亡率？

CJEM. 2021 Mar;23(2):164-165. doi: 10.1007/s43678-020-00053-z. Epub 2021 Jan 4.

Tranexamic acid for acute gastrointestinal bleeding (the HALT-IT trial): statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial.氨甲环酸用于急性胃肠道出血（HALT-IT试验）：一项国际随机双盲安慰剂对照试验的统计分析计划

Trials. 2019 Jul 30;20(1):467. doi: 10.1186/s13063-019-3561-7.

Pulmonary embolism associated with tranexamic acid in severe acquired haemophilia.严重获得性血友病中与氨甲环酸相关的肺栓塞

Eur J Haematol. 2002 May;68(5):307-9. doi: 10.1034/j.1600-0609.2002.01607.x.

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Efficacy and Safety of Tranexamic Acid in the Management of Gastrointestinal Bleeding: A Systematic Review.氨甲环酸治疗胃肠道出血的疗效与安全性：一项系统评价

Cureus. 2024 Dec 20;16(12):e76086. doi: 10.7759/cureus.76086. eCollection 2024 Dec.

Tranexamic acid: a narrative review of its current role in perioperative medicine and acute medical bleeding.氨甲环酸：关于其在围手术期医学和急性内科出血中当前作用的叙述性综述

Front Med (Lausanne). 2024 Aug 7;11:1416998. doi: 10.3389/fmed.2024.1416998. eCollection 2024.

Absence of hyperfibrinolysis may explain lack of efficacy of tranexamic acid in hypoproliferative thrombocytopenia.缺乏纤维蛋白溶解亢进可能解释了氨甲环酸在低增生性血小板减少症中无效。

Blood Adv. 2023 Mar 28;7(6):900-908. doi: 10.1182/bloodadvances.2022008255.

Fibrin clot quality in acutely ill cirrhosis patients: Relation with outcome and improvement with coagulation factor concentrates.急性肝衰竭患者的纤维蛋白凝块质量：与结局的关系以及凝血因子浓缩物的改善作用。

Liver Int. 2022 Feb;42(2):435-443. doi: 10.1111/liv.15132. Epub 2021 Dec 20.

Tranexamic acid evidence and controversies: An illustrated review.氨甲环酸的证据与争议：图文并茂的综述

Res Pract Thromb Haemost. 2021 Jul 14;5(5):e12546. doi: 10.1002/rth2.12546. eCollection 2021 Jul.

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Tranexamic acid in acute gastrointestinal bleeding - A cautionary tale.

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