Tsige Abate Wondesen, Endalifer Bedilu Linger, Habteweld Habtemariam Alekaw, Wondmkun Yehualashet Teshome, Ayele Siraye Genzeb, Kefale Belayneh
Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia.
Department of Midwifery, School of Nursing and Midwifery, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Front Pharmacol. 2024 Jul 29;15:1399177. doi: 10.3389/fphar.2024.1399177. eCollection 2024.
Globally, about 18 million people died from cardiovascular diseases (CVDs) in 2019, over three-quarters in developing countries. Non-adherence to medication in CVD patients causes hospitalization, worsened symptoms, higher healthcare costs, and more emergency visits. Hence, this study aimed to assess treatment satisfaction and medication adherence and predictors in heart failure (HF) patients attending Debre Berhan Comprehensive Specialized Hospital (DBCSH), Ethiopia.
A hospital-based cross-sectional study was undertaken at the medical referral clinic of DBCSH. A total of 344 ambulatory HF patients who visited the medical care of the DBCSH medical referral clinic during the study period were included. Treatment satisfaction was assessed using a self-administered Medicine Questionnaire (SATMED-Q). Relationships between predictor variables and treatment satisfaction were determined using one-way analysis of variance (ANOVA) and an independent -test. Medication adherence was determined using the Morisky Green Levin Medication Adherence Scale (MGLS).
Participants with drug-drug interactions (DDIs) were approximately 38% less likely to adhere to medication compared to their counterparts (AOR = 0.62, 95% CI: 0.54-0.71). Additionally, participants who had taken five or more drugs were approximately 68% less likely to adhere to medication compared to those who had taken only one drug (AOR = 0.32, 95% CI: 0.2-0.51). The correlation between medication adherence and drug-drug interactions remains a possible pseudo-correlation via the number of medications taken. There was a noteworthy positive correlation (rs = 0.34, = 0.027) between participants' treatment adherence and treatment satisfaction.
The rate of treatment satisfaction and treatment adherence among HF patients was 67.6% and 60.9%, respectively. The presence of DDI and the number of drugs were identified as predictors to medication adherence.
2019年，全球约有1800万人死于心血管疾病（CVD），其中超过四分之三发生在发展中国家。心血管疾病患者不坚持服药会导致住院、症状加重、医疗费用增加以及更多的急诊就诊。因此，本研究旨在评估埃塞俄比亚德布雷伯汉综合专科医院（DBCSH）心力衰竭（HF）患者的治疗满意度、药物依从性及其预测因素。
在DBCSH的医疗转诊诊所进行了一项基于医院的横断面研究。纳入了在研究期间到DBCSH医疗转诊诊所就诊的344名门诊心力衰竭患者。使用自行填写的药物问卷（SATMED-Q）评估治疗满意度。使用单因素方差分析（ANOVA）和独立样本t检验确定预测变量与治疗满意度之间的关系。使用莫利斯基-格林-莱文药物依从性量表（MGLS）确定药物依从性。
与无药物相互作用（DDIs）的参与者相比，存在药物相互作用的参与者坚持服药的可能性低约38%（调整后比值比[AOR]=0.62，95%置信区间[CI]：0.54-0.71）。此外，服用五种或更多药物的参与者与仅服用一种药物的参与者相比，坚持服药的可能性低约68%（AOR=0.32，95%CI：0.2-0.51）。药物依从性与药物相互作用之间的相关性可能是通过服用药物的数量产生的伪相关性。参与者的治疗依从性与治疗满意度之间存在显著的正相关（斯皮尔曼相关系数[rs]=0.34，P=0.0
