Department of Pulmonary Diseases and Children Rheumatology, Medical University of Lublin, Lublin, Poland.
Department of Pulmonary Diseases and Children Rheumatology, Medical University of Lublin, Lublin, Poland.
J Allergy Clin Immunol Pract. 2021 Jan;9(1):453-462. doi: 10.1016/j.jaip.2020.08.025. Epub 2020 Aug 26.
Recent studies highlight the immunoregulatory potential of bacterial lysates, indicating their potential use in the prevention and treatment of allergic diseases.
To investigate the clinical efficacy of polyvalent mechanical bacterial lysates (PMBLs) in children with grass pollen-induced allergic rhinitis.
Seventy children with seasonal allergic rhinitis were enrolled to this study and were randomly assigned to the PMBL and placebo groups. Severity of seasonal allergic rhinitis symptoms was assessed by the total nasal symptom score, total ocular symptom score, and visual analogue scale. During 3 visits, peak nasal inspiratory flow was measured, and nasal smears for the presence of eosinophils and nasal lavage fluids for the presence of allergen-specific IgE against timothy grass pollen allergens were sampled.
A statistically significant decrease in total nasal symptom score (P = .001), total ocular symptom score (P = .04), and visual analogue scale score for nasal and eye symptoms (P < .001 and P < .001, respectively) and an increase in peak nasal inspiratory flow (P = .04) were observed in the PMBL group versus the placebo group. During the grass pollen season, an increase and then a decrease in the number of eosinophils in nasal smears was observed in both groups; however, the number of eosinophils was significantly lower in the PMBL group versus the placebo group. No significant changes in allergen-specific IgE concentrations were observed in the PMBL group, whereas in the placebo group a statistically significant increase in allergen-specific IgE concentration was observed.
Sublingual administration of PMBLs during the grass pollen season offers significant efficacy in alleviating seasonal allergic rhinitis symptoms in children sensitized to grass pollen allergens. PMBLs probably affect mucosal immunity, weakening the response of T2 cells.
最近的研究强调了细菌裂解物的免疫调节潜力，表明它们有可能用于预防和治疗过敏性疾病。
研究多价机械细菌裂解物（PMBL）在花粉致敏的儿童变应性鼻炎中的临床疗效。
本研究纳入了 70 名季节性变应性鼻炎患儿，并将其随机分为 PMBL 组和安慰剂组。采用总鼻部症状评分、总眼部症状评分和视觉模拟评分评估季节性变应性鼻炎症状的严重程度。在 3 次就诊时测量鼻峰吸气流量，采集鼻拭子中嗜酸性粒细胞和鼻灌洗液中针对豚草花粉过敏原的特异性 IgE。
与安慰剂组相比，PMBL 组的总鼻部症状评分（P=0.001）、总眼部症状评分（P=0.04）和鼻、眼部症状的视觉模拟评分（P<0.001 和 P<0.001）均显著下降，鼻峰吸气流量增加（P=0.04）。在花粉季节，两组的鼻拭子中嗜酸性粒细胞数量均先增加后减少，但 PMBL 组的嗜酸性粒细胞数量明显低于安慰剂组。PMBL 组的过敏原特异性 IgE 浓度无明显变化，而安慰剂组的过敏原特异性 IgE 浓度显著升高。
在花粉季节舌下给予 PMBL 可显著缓解花粉致敏儿童的季节性变应性鼻炎症状。PMBL 可能影响黏膜免疫，减弱 T2 细胞的反应。
