Center of Immunology, Stefan S. Nicolau' Institute of Virology, 030304 Bucharest, Romania.
Department of Immunology, Victor Babeș' National Institute of Pathology, 050096 Bucharest, Romania.
Nutrients. 2020 Aug 26;12(9):2596. doi: 10.3390/nu12092596.
Natural compounds can modulate all three major phases of carcinogenesis. The role of the natural compounds such as resveratrol (RSV) and curcumin (CRM) in modulation of anticancer potential of platinum-based drugs (CisPt) is still a topic of considerable debate. In order to enhance head and neck cancer (HNSCC) cells' sensitivity to the cytotoxic effects of CisPt combined treatments with RSV or CRM were used. The study aim was to evaluate how the RSV or CRM associated to CisPt treatment modulated some cellular processes such as proliferation, P21 gene expression, apoptotic process, and cell cycle development in HNSCC tumor cell line (PE/CA-PJ49) compared to a normal cell line (HUVEC). The results showed that RSV or CRM treatment affected the viability of tumor cells more than normal cells. These natural compounds act against proliferation and sustain the effects of cisplatin by cell cycle arrest, induction of apoptosis and amplification of P21 expression in tumor cells. In conclusion, using RSV or CRM as adjuvants in CisPt therapy might have a beneficial effect by supporting the effects induced by CisPt.
天然化合物可以调节致癌作用的所有三个主要阶段。目前仍在讨论白藜芦醇（RSV）和姜黄素（CRM）等天然化合物在调节基于铂的抗癌药物（顺铂）的抗癌潜力中的作用。为了提高头颈部癌症（HNSCC）细胞对顺铂细胞毒性作用的敏感性，联合使用 RSV 或 CRM 进行治疗。本研究旨在评估 RSV 或 CRM 与顺铂联合治疗如何调节某些细胞过程，如增殖、P21 基因表达、细胞凋亡过程和细胞周期进展，与正常细胞系（HUVEC）相比，在 HNSCC 肿瘤细胞系（PE/CA-PJ49）中。结果表明，RSV 或 CRM 处理比正常细胞更能影响肿瘤细胞的活力。这些天然化合物通过细胞周期阻滞、诱导凋亡和扩增肿瘤细胞中 P21 的表达来对抗增殖并维持顺铂的作用。总之，将 RSV 或 CRM 用作 CisPt 治疗的佐剂可能会通过支持 CisPt 诱导的作用产生有益的效果。
