Department of Radiological Medicine, Chongqing Medical UniversityChongqingChina.
Department of Gynecologic Oncology, Chongqing Cancer InstituteChongqingChina.
Oncol Res. 2020 Sep 1;28(4):447-449. doi: 10.3727/096504020X15970683241756.
It has been demonstrated that microRNAs (miRNAs) act as oncogenes or tumor suppressors in a variety of cancers. Our previous work suggested that miR-10a/b functioned as a tumor suppressor in gastric cancer, and miR-10b was also reported to be significantly downregulated in advanced stage cervical cancer tissues. However, the aberrant expression of miR-10b in cervical cancer and its possible role in cervical carcinogenesis was largely unknown. In this study, we investigated the expression of miR-10b in cervical cancer tissues, carcinoma in situ tissues, mild dysplasia, moderate dysplasia, severe dysplasia tissues, and normal controls. We found that miR-10b was significantly downregulated during cervical cancer progression, and the lower level of miR-10b in cervical cancer was significantly associated with a more aggressive tumor phenotype. Moreover, overexpression of miR-10b in cervical cancer cells could inhibit the cell proliferation and invasion, and the further mechanism study suggested that its role was possibly through directly targeting HOXA1. These results suggested that the downregulation of miR-10b and the resulting elevated HOXA1 level in cervical cancer tissues might play critical roles in cervical cancer progression.
已经证实，microRNAs（miRNAs）在多种癌症中充当癌基因或肿瘤抑制因子。我们之前的研究表明 miR-10a/b 在胃癌中作为肿瘤抑制因子发挥作用，并且 miR-10b 在晚期宫颈癌组织中也被报道显著下调。然而，miR-10b 在宫颈癌中的异常表达及其在宫颈癌发生中的可能作用在很大程度上是未知的。在这项研究中，我们调查了 miR-10b 在宫颈癌组织、原位癌组织、轻度不典型增生、中度不典型增生、重度不典型增生组织和正常对照中的表达。我们发现 miR-10b 在宫颈癌进展过程中显著下调，并且宫颈癌中 miR-10b 的低水平与更具侵袭性的肿瘤表型显著相关。此外，在宫颈癌细胞中过表达 miR-10b 可抑制细胞增殖和侵袭，进一步的机制研究表明其作用可能是通过直接靶向 HOXA1。这些结果表明，miR-10b 在宫颈癌组织中的下调以及由此导致的 HOXA1 水平升高可能在宫颈癌进展中发挥关键作用。
