Efficacy of alginate-and chitosan-based scaffolds on the healing of diabetic skin wounds in animal experimental models and cell studies: A systematic review.

This systematic literature review was aimed to investigate the use of cell culture and animal models to evaluate the efficacy of alginate-and chitosan-based scaffolds on diabetic wound healing. We electronically searched the articles published until July 2019. The databases included five English databases such as PubMed, Web of Science, Embase, the Cochrane Library, CINAHL, and three Chinese databases like CNKI, WanFang Data, and VIP. The related articles were manually searched to identify studies that were not searched by electronic database searches. Twenty-nine studies met the inclusion criteria. We divided the results into three groups: chitosan, alginate, and a combination of chitosan and alginate. Chitosan-, alginate-, and a combination of chitosan and alginate-based scaffolds showed good intervention effects on wound healing. Chitosan-based scaffolds were effective in diabetic skin wound healing. The effects of alginate and the combination of chitosan-and alginate-based scaffolds on diabetic skin wounds still need more research. However, due to the heterogeneity of animal and cell preclinical trials and the validity of the statistical analysis used in these studies, it is necessary to conduct a thorough study using well-designed experiments to confirm these results. In addition, properly designed chitosan-and/or alginate-based scaffolds with thorough preclinical evaluations are required prior to clinical applications.