School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India.
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Biomed Res Int. 2022 Jul 4;2022:1659338. doi: 10.1155/2022/1659338. eCollection 2022.
Diabetic wound (DW) is a secondary application of uncontrolled diabetes and affects about 42.2% of diabetics. If the disease is left untreated/uncontrolled, then it may further lead to amputation of organs. In recent years, huge research has been done in the area of wound dressing to have a better maintenance of DW. These include gauze, films, foams or, hydrocolloid-based dressings as well as polysaccharide- and polymer-based dressings. In recent years, scaffolds have played major role as biomaterial for wound dressing due to its tissue regeneration properties as well as fluid absorption capacity. These are three-dimensional polymeric structures formed from polymers that help in tissue rejuvenation. These offer a large surface area to volume ratio to allow cell adhesion and exudate absorbing capacity and antibacterial properties. They also offer a better retention as well as sustained release of drugs that are directly impregnated to the scaffolds or the ones that are loaded in nanocarriers that are impregnated onto scaffolds. The present review comprehensively describes the pathogenesis of DW, various dressings that are used so far for DW, the limitation of currently used wound dressings, role of scaffolds in topical delivery of drugs, materials used for scaffold fabrication, and application of various polymer-based scaffolds for treating DW.
糖尿病创面（DW）是糖尿病失控的继发症，约影响 42.2%的糖尿病患者。如果不进行治疗/控制，可能会导致器官的截肢。近年来，在创面敷料领域进行了大量的研究，以更好地维持 DW。这些敷料包括纱布、薄膜、泡沫或水胶体敷料以及多糖和聚合物敷料。近年来，由于其组织再生特性和流体吸收能力，支架作为生物材料在创面敷料中发挥了主要作用。这些是由聚合物形成的三维聚合物结构，有助于组织再生。它们提供了较大的表面积与体积比，允许细胞黏附和渗出液吸收能力以及抗菌性能。它们还能更好地保留和持续释放直接浸渍到支架上的药物，或者负载在纳米载体上并浸渍到支架上的药物。本综述全面描述了 DW 的发病机制、迄今为止用于 DW 的各种敷料、目前使用的创面敷料的局限性、支架在药物局部递送上的作用、用于支架制造的材料以及各种基于聚合物的支架在治疗 DW 中的应用。
