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使用混合模拟方法对痴呆症护理需求异质性进行计算机模拟:利用个体患者衰退轨迹改善人群水平建模。

Computer simulation of dementia care demand heterogeneity using hybrid simulation methods: improving population-level modelling with individual patient decline trajectories.

机构信息

Southampton Business School, University of Southampton, Southampton, UK; School of Health Sciences, University of Southampton, Southampton, UK.

Southampton Business School, University of Southampton, Southampton, UK.

出版信息

Public Health. 2020 Sep;186:197-203. doi: 10.1016/j.puhe.2020.07.018. Epub 2020 Aug 27.

Abstract

OBJECTIVES

The aim of the study was to model dementia prevalence and outcomes within an ageing population using a novel hybrid simulation model that simultaneously takes population-level and patient-level perspectives to better inform dementia care service planning, taking into account severity progression variability.

STUDY DESIGN

This is a simulation study.

METHODS

We developed a hybrid computer simulation combining different methods to best represent population and individual dementia dynamics. Individual patient outcomes are aggregated into three progression rate types to report the effects of severity progression variability and intervention benefits.

RESULTS

Fast progression of dementia severity is associated with higher annual care cost and short overall survival duration. Those patients are more likely to develop moderate to severe symptoms more quickly, highlighting a need for more urgent provision of appropriate care services. Slower severity progression is associated with lower annual care costs, but longer survival requires higher overall financial provision. Although lifestyle interventions reduce overall care costs, treatment and lifestyle intervention benefits are modest at the population level.

CONCLUSIONS

Individual variation of dementia decline is an important factor to include in planning adequate levels of care services and to ensure timely and appropriate service availability. Hybrid simulation models provide useful insights at the population and individual level, supporting effective decision-making.

摘要

目的

本研究旨在建立一种新型混合仿真模型,从人群和个体两个角度来模拟痴呆症的流行程度和结局,从而更好地为痴呆症护理服务规划提供信息,同时考虑严重程度进展的可变性。

研究设计

这是一项仿真研究。

方法

我们开发了一种混合计算机仿真模型,结合了不同的方法来最好地代表人群和个体的痴呆症动态。将个体患者的结局汇总为三种进展速度类型,以报告严重程度进展变异性和干预效益的影响。

结果

痴呆症严重程度的快速进展与较高的年度护理成本和较短的总生存时间相关。这些患者更有可能更快地发展为中度至重度症状,突出了更迫切地提供适当护理服务的必要性。严重程度进展较慢与较低的年度护理成本相关,但更长的生存时间需要更高的总体资金提供。尽管生活方式干预降低了总体护理成本,但治疗和生活方式干预的效益在人群水平上是适度的。

结论

痴呆症衰退的个体差异是规划适当护理服务水平以及确保及时和适当服务提供的重要因素。混合仿真模型在人群和个体水平上提供了有用的见解,支持有效的决策制定。

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