Armenian Medical Institute, Titogradyan 14, Yerevan, Republic of Armenia.
Urgent Cardiology Department, "Erebouni" Medical Center, Titogradyan 14, Yerevan, Republic of Armenia.
Int J Biometeorol. 2020 Dec;64(12):2171-2176. doi: 10.1007/s00484-020-02009-5. Epub 2020 Aug 29.
One hundred patients with ischemic heart disease and 70 healthy subjects were on unified regimen. Urine was collected with 4-h proportions during 3-5 days (72-120 h). Each portion of urine was analyzed for macro- (Na, K, P, Cl, Ca, Mg) and microelements (Fe, Cu, Zn, Cr, Cd, V). Temporal structure (biological and hydrometeorological indices) parameters have been estimated by nonlinear least squares method for sinusoidal rhythms and dispersion analysis for nonsinusoidal rhythms. Data of weather indices were received from the hydrometeorological service of the Republic of Armenia in 2015 at 3-h intervals. Statistically significant rhythms were observed in healthy subjects in 91% cases of 593 rhythmological investigations of water-mineral homeostasis. Acrophases of water-mineral homeostasis mostly had individual nature. Healthy subjects' rhythms of water-mineral excretion were depending on rhythms of hydrometeorological indices and were characterized with significant correlative connections. Acrophases of indices of water-mineral homeostasis mostly were outstripping the acrophases of the rhythms of hydrometeorological indices. Chronostructure of water-mineral homeostasis in patients with ischemic heart disease was characterized with infradian and circadian fluctuations. In case of individuals with ischemic heart disease, statistically significant correlative connections between rhythms of water-mineral excretion and rhythms of hydrometeorological indices differ in comparison with the results of practically healthy individuals. In patients with ischemic heart disease, acrophases of biorhythms often were concurrent or delayed relative to the acrophases of the rhythms of hydrometeorological indices.
一百名缺血性心脏病患者和 70 名健康受试者接受了统一的治疗方案。在 3-5 天（72-120 小时）期间，按 4 小时的比例收集尿液。分析每部分尿液中的宏量元素（Na、K、P、Cl、Ca、Mg）和微量元素（Fe、Cu、Zn、Cr、Cd、V）。通过非线性最小二乘法估计了时间结构（生物和水文气象指标）参数，对非正弦节律进行了离散分析。2015 年，在每 3 小时接收一次亚美尼亚共和国水文气象服务数据的情况下，对天气指数数据进行了研究。在对 593 次水盐稳态节律学调查的 91%的健康受试者中观察到了有统计学意义的节律。水盐稳态的峰相位大多具有个体性。健康受试者的水盐排泄节律取决于水文气象指标的节律，并具有显著的相关关系。水盐稳态指标的峰相位大多超过了水文气象指标节律的峰相位。缺血性心脏病患者的水盐稳态时间结构表现为近昼夜和昼夜波动。在缺血性心脏病患者中，与健康个体相比，水盐排泄节律与水文气象节律之间的统计学显著相关关系有所不同。在缺血性心脏病患者中，生物节律的峰相位往往与水文气象节律的峰相位同时出现或延迟。
