Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, School of Petrochemical Engineering, Changzhou University, Changzhou, China.
Zaozhuang Key Laboratory of Corn Bioengineering, Zaozhuang Science and Technology Collaborative Innovation Center of Enzyme, Shandong Hengren Gongmao Co. Ltd, Zaozhuang, China.
Crit Rev Biotechnol. 2020 Dec;40(8):1151-1162. doi: 10.1080/07388551.2020.1813071. Epub 2020 Aug 30.
Efficient cell factories are the core of industrial biotechnology. In recent years, synthetic biology develops rapidly, and more and more modified microbial cell factories are employed in industrial biotechnology. ATP plays vital roles in biosynthesis, metabolism regulation, and cellular maintenance. Regulating cellular ATP supply can effectively modify cellular metabolism. This paper presents a review of recent studies on the regulation of the intracellular ATP supply and its application in industrial biotechnology. Detailed strategies for regulating the ATP supply and the resulting impact on bioproduction are introduced. It is observed that regulating the cellular ATP supply can provide great possibilities for making microbial cells into efficient factories. Future perspectives for further understanding the function of ATP are also discussed.
高效的细胞工厂是工业生物技术的核心。近年来，合成生物学发展迅速，越来越多的经过改造的微生物细胞工厂被应用于工业生物技术中。ATP 在生物合成、代谢调控和细胞维持中起着至关重要的作用。调节细胞内 ATP 的供应可以有效地改变细胞的代谢。本文综述了近年来关于调节细胞内 ATP 供应及其在工业生物技术中的应用的研究。介绍了调节 ATP 供应的详细策略以及对生物生产的影响。研究表明，调节细胞内 ATP 的供应可以为使微生物细胞成为高效工厂提供巨大的可能性。还讨论了进一步了解 ATP 功能的未来展望。
