Wada Kento, Tsuda Takeshi, Hanada Yukiko, Mori Kiyoshi, Nishimura Hiroshi
Department of Otorhinolaryngology, 13707National Hospital Organization Osaka National Hospital, Osaka City, Osaka, Japan.
Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan.
Ear Nose Throat J. 2022 May;101(4):NP149-NP152. doi: 10.1177/0145561320954128. Epub 2020 Aug 30.
External auditory canal cancer is a rare disease which can be treated by surgery or chemoradiation. The most common histological type is squamous cell carcinoma, but rare types such as adenocarcinoma have been reported and are thought to be derived from the ceruminous glands. Here, we present a case of ceruminous adenocarcinoma, not otherwise specified (NOS) in the external auditory canal. A 72-year-old woman was referred to our department with discomfort due to a mass in the external ear canal. No typical symptoms of malignancy, such as pain or bleeding, were noted at the initial examination. The patient underwent a total excision under local anesthesia as a diagnostic treatment. She was diagnosed with ceruminous adenocarcinoma, NOS based on the results of immunostaining of the excised specimen, and is currently being followed up as an outpatient. Adenocarcinoma is thought to originate from the cerumen glands of the ear canal and the lack of specific symptoms may make it difficult to differentiate it from benign tumors. Although adenocarcinoma, NOS has been reported in the head and neck region, there have been no reported cases occurring in the external ear canal, and to the best of our knowledge, this is the first report.
外耳道癌是一种罕见疾病，可通过手术或放化疗进行治疗。最常见的组织学类型是鳞状细胞癌，但也有报道称存在腺癌等罕见类型，且认为其起源于耵聍腺。在此，我们报告一例外耳道未另行特指（NOS）的耵聍腺癌病例。一名72岁女性因外耳道肿物不适前来我院就诊。初诊时未发现疼痛或出血等典型恶性症状。患者在局部麻醉下接受了全切除作为诊断性治疗。根据切除标本的免疫染色结果，她被诊断为耵聍腺癌，NOS，目前作为门诊患者进行随访。腺癌被认为起源于耳道的耵聍腺，且缺乏特异性症状可能使其难以与良性肿瘤相鉴别。尽管头颈部区域已报道过NOS腺癌，但外耳道尚未见报道，据我们所知，这是首例报告。
