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新型冠状病毒肺炎患者尸检结果综述

A Review of Postmortem Findings in Patients With COVID-19.

作者信息

Eketunde Adenike O, Mellacheruvu Sai Priyanka, Oreoluwa Philip

机构信息

Public Health, University of Massachusetts Lowell, Lowell, USA.

Public Health, John Hopkins School of Public Health, Baltimore, USA.

出版信息

Cureus. 2020 Jul 28;12(7):e9438. doi: 10.7759/cureus.9438.

Abstract

Multiple public health problems have been caused by various coronavirus strains over the last few years, such as the middle eastern respiratory syndrome (MERS), severe acute respiratory syndrome (SARS), and COVID-19. COVID-19, which is also known as coronavirus disease 2019, was first detected in Wuhan, China, and has significantly impacted people's health and lives. Additionally, it has led to a pandemic, and the virus has spread to over 121 countries worldwide. There is numerous information available regarding this virus. A detailed and extensive study of the morphological and histopathological findings will help understand and diagnose the disease. As it is a new disease, it is challenging to understand the mechanism of the action and disease pathology due to the limited availability of data from autopsies or biopsies. However, as the detailed mechanism of injury remains unclear, this paper aims to review the postmortem gross and histopathological findings of various organs that have been affected with coronavirus, focusing on the pulmonary, cardiac, and hematologic findings. This paper emphasizes the postmortem findings of the effect of the coronavirus disease on multiple organ systems. Advance search of the keywords on PubMed was used, limiting the search to the last five years. The eligible article is narrowed based on relevance containing postmortem findings of the novel virus; COVID-19. A total of 25 full-text articles were selected and used in the review of this paper.

摘要

在过去几年中,多种冠状病毒毒株引发了诸多公共卫生问题,如中东呼吸综合征(MERS)、严重急性呼吸综合征(SARS)以及新型冠状病毒肺炎(COVID-19)。新型冠状病毒肺炎,也被称为2019冠状病毒病,最初在中国武汉被发现,对人们的健康和生活产生了重大影响。此外,它还引发了一场全球大流行,该病毒已传播至全球121多个国家。关于这种病毒有大量信息。对其形态学和组织病理学发现进行详细而广泛的研究将有助于理解和诊断该疾病。由于这是一种新疾病,尸检或活检数据有限,因此了解其作用机制和疾病病理学具有挑战性。然而,由于损伤的详细机制仍不清楚,本文旨在综述受冠状病毒影响的各个器官的尸检大体及组织病理学发现,重点关注肺部、心脏和血液学方面的发现。本文强调了冠状病毒病对多个器官系统影响的尸检结果。通过在PubMed上对关键词进行高级搜索,将搜索范围限制在过去五年。符合条件的文章根据相关性进行筛选,这些文章包含新型病毒——COVID-19的尸检结果。总共选择了25篇全文文章用于本文的综述。

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