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Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.在流行地区,服用抗叶酸抗疟药物的人群中,叶酸补充剂与疟疾易感性和严重程度的关系。
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Postmortem findings in COVID-19 fatalities: A systematic review of current evidence.COVID-19 死亡病例的尸检结果:当前证据的系统回顾。
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Post-mortem findings in Spanish patients with COVID-19; a special focus on superinfections.西班牙新冠肺炎患者的尸检结果;特别关注重叠感染。
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Nutrients, herbal bioactive derivatives and commensal microbiota as tools to lower the risk of SARS-CoV-2 infection.营养物质、草药生物活性衍生物和共生微生物群作为降低新型冠状病毒感染风险的工具。
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本文引用的文献

1
Autopsy Findings and Venous Thromboembolism in Patients With COVID-19.新型冠状病毒肺炎患者的尸检结果与静脉血栓栓塞
Ann Intern Med. 2020 Dec 15;173(12):1030. doi: 10.7326/L20-1206.
2
Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans.非裔美国人 COVID-19 患者的肺部和心脏病理学:来自新奥尔良的尸检系列。
Lancet Respir Med. 2020 Jul;8(7):681-686. doi: 10.1016/S2213-2600(20)30243-5. Epub 2020 May 27.
3
Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology.COVID-19 的神经病理学:一系列血管和急性播散性脑脊髓炎(ADEM)样病变。
Acta Neuropathol. 2020 Jul;140(1):1-6. doi: 10.1007/s00401-020-02166-2. Epub 2020 May 24.
4
Pulmonary and systemic involvement in COVID-19 patients assessed with ultrasound-guided minimally invasive autopsy.超声引导下微创尸检评估COVID-19患者的肺部和全身受累情况。
Histopathology. 2020 Aug;77(2):186-197. doi: 10.1111/his.14160. Epub 2020 Jul 24.
5
The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities.新型冠状病毒病 2019(COVID-19)的心肺病理学:来自德克萨斯州休斯顿的 3 例尸检报告,并回顾了美国其他城市的尸检结果。
Cardiovasc Pathol. 2020 Sep-Oct;48:107233. doi: 10.1016/j.carpath.2020.107233. Epub 2020 May 7.
6
Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome : Results From a Prospective, Single-Center, Clinicopathologic Case Series.COVID-19 相关肺动脉血栓栓塞导致的致命结局:一项前瞻性、单中心、临床病理病例系列研究的结果。
Ann Intern Med. 2020 Sep 1;173(5):350-361. doi: 10.7326/M20-2566. Epub 2020 May 14.
7
Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan.日本 COVID-19 患者尸检的临床病理和免疫组织化学检查结果。
Emerg Infect Dis. 2020 Sep;26(9):2157-61. doi: 10.3201/eid2609.201353. Epub 2020 May 15.
8
Fatal Eosinophilic Myocarditis in a Healthy 17-Year-Old Male with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2c).一名17岁健康男性患严重急性呼吸综合征冠状病毒2(SARS-CoV-2c)导致的致命性嗜酸性粒细胞性心肌炎
Fetal Pediatr Pathol. 2020 Jun;39(3):263-268. doi: 10.1080/15513815.2020.1761491. Epub 2020 May 13.
9
Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages.COVID-19 患者的病理性炎症:单核细胞和巨噬细胞的关键作用。
Nat Rev Immunol. 2020 Jun;20(6):355-362. doi: 10.1038/s41577-020-0331-4. Epub 2020 May 6.
10
Ultrastructural Evidence for Direct Renal Infection with SARS-CoV-2.SARS-CoV-2 直接肾感染的超微结构证据。
J Am Soc Nephrol. 2020 Aug;31(8):1683-1687. doi: 10.1681/ASN.2020040432. Epub 2020 May 5.

新型冠状病毒肺炎患者尸检结果综述

A Review of Postmortem Findings in Patients With COVID-19.

作者信息

Eketunde Adenike O, Mellacheruvu Sai Priyanka, Oreoluwa Philip

机构信息

Public Health, University of Massachusetts Lowell, Lowell, USA.

Public Health, John Hopkins School of Public Health, Baltimore, USA.

出版信息

Cureus. 2020 Jul 28;12(7):e9438. doi: 10.7759/cureus.9438.

DOI:10.7759/cureus.9438
PMID:32864262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7451084/
Abstract

Multiple public health problems have been caused by various coronavirus strains over the last few years, such as the middle eastern respiratory syndrome (MERS), severe acute respiratory syndrome (SARS), and COVID-19. COVID-19, which is also known as coronavirus disease 2019, was first detected in Wuhan, China, and has significantly impacted people's health and lives. Additionally, it has led to a pandemic, and the virus has spread to over 121 countries worldwide. There is numerous information available regarding this virus. A detailed and extensive study of the morphological and histopathological findings will help understand and diagnose the disease. As it is a new disease, it is challenging to understand the mechanism of the action and disease pathology due to the limited availability of data from autopsies or biopsies. However, as the detailed mechanism of injury remains unclear, this paper aims to review the postmortem gross and histopathological findings of various organs that have been affected with coronavirus, focusing on the pulmonary, cardiac, and hematologic findings. This paper emphasizes the postmortem findings of the effect of the coronavirus disease on multiple organ systems. Advance search of the keywords on PubMed was used, limiting the search to the last five years. The eligible article is narrowed based on relevance containing postmortem findings of the novel virus; COVID-19. A total of 25 full-text articles were selected and used in the review of this paper.

摘要

在过去几年中,多种冠状病毒毒株引发了诸多公共卫生问题,如中东呼吸综合征(MERS)、严重急性呼吸综合征(SARS)以及新型冠状病毒肺炎(COVID-19)。新型冠状病毒肺炎,也被称为2019冠状病毒病,最初在中国武汉被发现,对人们的健康和生活产生了重大影响。此外,它还引发了一场全球大流行,该病毒已传播至全球121多个国家。关于这种病毒有大量信息。对其形态学和组织病理学发现进行详细而广泛的研究将有助于理解和诊断该疾病。由于这是一种新疾病,尸检或活检数据有限,因此了解其作用机制和疾病病理学具有挑战性。然而,由于损伤的详细机制仍不清楚,本文旨在综述受冠状病毒影响的各个器官的尸检大体及组织病理学发现,重点关注肺部、心脏和血液学方面的发现。本文强调了冠状病毒病对多个器官系统影响的尸检结果。通过在PubMed上对关键词进行高级搜索,将搜索范围限制在过去五年。符合条件的文章根据相关性进行筛选,这些文章包含新型病毒——COVID-19的尸检结果。总共选择了25篇全文文章用于本文的综述。