用于生物成像的小分子近红外探针的最新进展
Recent Progress in Small-Molecule Near-IR Probes for Bioimaging.
作者信息
Li Jun-Bin, Liu Hong-Wen, Fu Ting, Wang Ruowen, Zhang Xiao-Bing, Tan Weihong
机构信息
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Institute of Molecular Medicine, Renji Hospital, School of Medicine and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
出版信息
Trends Chem. 2019 May;1(2):224-234. doi: 10.1016/j.trechm.2019.03.002. Epub 2019 Apr 5.
Abstract
Small-molecule near-IR (NIR) optical imaging has experienced tremendous advancements over the past two decades, playing important roles in both theory and application in the biomedical field. NIR optical imaging affords improved contrast and depth of tissue penetration by reducing photon scattering, lowering tissue absorption, and minimizing autofluorescence in the NIR window. Moreover, molecular engineering endows small-molecule probes with powerful tunability, providing a valuable means for real-time noninvasive visualization of various biological processes and analytes with high sensitivity and resolution. In this review, we focus on the most recent advances in the development of small-molecule NIR probes and their applications in bioimaging. We also highlight the challenges and opportunities in this rapidly developing field.
摘要
在过去二十年中，小分子近红外（NIR）光学成像取得了巨大进展，在生物医学领域的理论和应用方面都发挥着重要作用。近红外光学成像通过减少光子散射、降低组织吸收以及最小化近红外窗口中的自发荧光，提高了对比度和组织穿透深度。此外，分子工程赋予小分子探针强大的可调性，为实时无创可视化各种生物过程和分析物提供了一种具有高灵敏度和分辨率的宝贵手段。在本综述中，我们重点关注小分子近红外探针开发的最新进展及其在生物成像中的应用。我们还强调了这个快速发展领域中的挑战和机遇。
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1
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2
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J Am Chem Soc. 2019 Jan 16;141(2):1126-1134. doi: 10.1021/jacs.8b12136. Epub 2019 Jan 2.
3
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4
Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging.小分子酶荧光探针用于癌症成像的最新进展。
Chem Soc Rev. 2018 Sep 17;47(18):7140-7180. doi: 10.1039/c7cs00862g.
5
Organic Semiconducting Agents for Deep-Tissue Molecular Imaging: Second Near-Infrared Fluorescence, Self-Luminescence, and Photoacoustics.用于深层组织分子成像的有机半导体试剂：第二近红外荧光、自发光和光声。
Adv Mater. 2018 Dec;30(49):e1801778. doi: 10.1002/adma.201801778. Epub 2018 Jul 29.
6
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Chem Sci. 2016 Sep 1;7(9):6203-6207. doi: 10.1039/c6sc01561a. Epub 2016 Jun 16.
7
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Angew Chem Int Ed Engl. 2018 Aug 6;57(32):10137-10141. doi: 10.1002/anie.201804731. Epub 2018 Jul 16.
9
A unique approach toward near-infrared fluorescent probes for bioimaging with remarkably enhanced contrast.一种用于生物成像的近红外荧光探针的独特方法，具有显著增强的对比度。
Chem Sci. 2016 Mar 1;7(3):2275-2285. doi: 10.1039/c5sc04014k. Epub 2016 Jan 4.
10
Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging.用于多功能生物医学成像的近红外二区荧光团的最新进展。
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