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血清β2-微球蛋白升高——持续性全身性淋巴结病患者发生艾滋病的预后标志物。

Elevated serum beta-2-microglobulin--a prognostic marker for development of AIDS among patients with persistent generalized lymphadenopathy.

作者信息

Morfeldt-Månson J, Julander I, von Stedingk L V, Wasserman J, Nilsson B

机构信息

Department of Infectious Diseases, Roslagstull Hospital, Karolinska Institute, Stockholm.

出版信息

Infection. 1988 Mar-Apr;16(2):109-10. doi: 10.1007/BF01644315.

DOI:10.1007/BF01644315
PMID:3286507
Abstract

For evaluation of its prognostic value, the level of serum beta-2-microglobulin was determined in early serum samples from 88 patients with persistent generalized lymphadenopathy in a prospective longitudinal study. Patients with serum beta-2-microglobulin greater than 2.6 mg/l were found to have a significantly higher risk of developing AIDS earlier when compared to patients with a lower level (p less than 0.001).

摘要

为评估其预后价值，在一项前瞻性纵向研究中，对88例持续性全身淋巴结肿大患者的早期血清样本测定了血清β2微球蛋白水平。发现血清β2微球蛋白大于2.6mg/L的患者与水平较低的患者相比，更早发展为艾滋病的风险显著更高（p<0.001）。

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本文引用的文献

1
Beta-2-microglobulin concentrations correlate with helper T cell counts in blood of homosexual men.
J Clin Lab Immunol. 1984 Sep;15(1):55-6.
2
Classification system for human T-lymphotropic virus type III/lymphadenopathy-associated virus infections.人类嗜T淋巴细胞病毒III型/淋巴结病相关病毒感染的分类系统
MMWR Morb Mortal Wkly Rep. 1986 May 23;35(20):334-9.
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Serum beta-2 microglobulin levels in homosexual men with AIDS and with persistent, generalized lymphadenopathy.患有艾滋病且伴有持续性全身性淋巴结病的同性恋男性的血清β-2微球蛋白水平
人类免疫缺陷病毒（HIV）感染不同阶段患者中人类疱疹病毒和乙型肝炎病毒抗体的流行情况。
Infection. 1991 May-Jun;19(3):140-5. doi: 10.1007/BF01643233.
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Beta 2-microglobulin as a prognostic marker for development of AIDS.β2-微球蛋白作为艾滋病发展的预后标志物。
Clin Chem. 1985 Aug;31(8):1411-2.
5
Serum neopterin and beta 2-microglobulin in anti-HIV positive blood donors.抗HIV阳性献血者的血清新蝶呤和β2-微球蛋白
Lancet. 1986 Nov 22;2(8517):1216. doi: 10.1016/s0140-6736(86)92219-1.
6
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.需要对每位患者进行长期观察的随机临床试验的设计与分析。II. 分析与示例。
Br J Cancer. 1977 Jan;35(1):1-39. doi: 10.1038/bjc.1977.1.