Zhan Ting, Liu Meng, Tang Yalin, Han Zheng, Cheng Xueting, Deng Junsheng, Chen Xiaoli, Tian Xia, Huang Xiaodong
Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.
Jianghan University, Wuhan, China.
J Int Med Res. 2020 Aug;48(8):300060520949039. doi: 10.1177/0300060520949039.
This study was performed to investigate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
We analyzed the electronic medical records of 405 hospitalized patients with laboratory-confirmed COVID-19 in the Third Hospital of Wuhan.
The patients' median age was 56 years, 54.1% were female, 11.4% had a history of smoking, and 10.6% had a history of drinking. All cases of COVID-19 were community-acquired. Fever (76.8%) and cough (53.3%) were the most common clinical manifestations, and circulatory system diseases were the most common comorbidities. Gastrointestinal symptoms were present in 61.2% of the patients, and 2.9% of the patients were asymptomatic. Computed tomography showed ground-glass opacities in most patients (72.6%) and consolidation in 30.9%. Lymphopenia (72.3%) and hypoproteinemia (71.6%) were observed in most patients. About 20% of patients had abnormal liver function. Patients with severe disease had significantly more prominent laboratory abnormalities, including an abnormal lymphocyte count and abnormal C-reactive protein, procalcitonin, alanine aminotransferase, aspartate aminotransferase, D-dimer, and albumin levels.
SARS-CoV-2 causes a variety of severe respiratory illnesses similar to those caused by SARS-CoV-1. Older age, chronic comorbidities, and laboratory abnormalities are associated with disease severity.
本研究旨在调查由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）患者的临床特征。
我们分析了武汉第三医院405例实验室确诊的COVID-19住院患者的电子病历。
患者的中位年龄为56岁，54.1%为女性，11.4%有吸烟史，10.6%有饮酒史。所有COVID-19病例均为社区获得性。发热（76.8%）和咳嗽（53.3%）是最常见的临床表现，循环系统疾病是最常见的合并症。61.2%的患者出现胃肠道症状，2.9%的患者无症状。计算机断层扫描显示大多数患者（72.6%）有磨玻璃影，30.9%有实变。大多数患者出现淋巴细胞减少（72.3%）和低蛋白血症（71.6%）。约20%的患者肝功能异常。重症患者的实验室异常更为明显，包括淋巴细胞计数异常以及C反应蛋白、降钙素原、谷丙转氨酶、谷草转氨酶、D-二聚体和白蛋白水平异常。
SARS-CoV-2引起多种严重的呼吸系统疾病，类似于SARS-CoV-1引起的疾病。老年、慢性合并症和实验室异常与疾病严重程度相关。
