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Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial.干扰素 beta-1b、洛匹那韦利托那韦和利巴韦林三联治疗住院 COVID-19 患者：一项开放标签、随机、2 期试验。
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Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages.COVID-19 患者的病理性炎症：单核细胞和巨噬细胞的关键作用。
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Racial Capitalism: A Fundamental Cause of Novel Coronavirus (COVID-19) Pandemic Inequities in the United States.种族资本主义：美国新冠病毒大流行不平等现象的根本原因。
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COVID-19 exacerbating inequalities in the US.新冠疫情加剧美国的不平等现象。
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SARS-CoV-2 感染中的免疫反应：I 型和 III 型干扰素的作用。

Immune response in SARS-CoV-2 infection: the role of interferons type I and type III.

机构信息

Universidade Federal do Piauí, Centro de Ciências da Saúde, Departamento de Parasitologia e Microbiologia, Teresina, PI, Brazil.

Universidade Federal da Bahia, Faculdade de Medicina, Laboratório de Pesquisa em Infectologia (LAPI), Salvador, BA, Brazil.

出版信息

Braz J Infect Dis. 2020 Sep-Oct;24(5):428-433. doi: 10.1016/j.bjid.2020.07.011. Epub 2020 Aug 26.

DOI:10.1016/j.bjid.2020.07.011
PMID:32866437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7448817/
Abstract

BACKGROUND

There is scarce information on the human immune response to the SARS-CoV-2 infection, and on the exacerbated inflammatory reaction observed in severe COVID-19 cases.

OBJECTIVE

To review the available evidence on the role of interferons type I and type III to SARS-CoV-2 infection.

METHODS

We reviewed the available published evidence on the role of immune response to SARS-CoV-2 infection as well as recent publications on characteristics and outcomes of COVID-19, and their relationship with interferons type I and type III.

RESULTS

The available data indicates that immune response plays an important role in controlling SARS-CoV-2 infection and the immune dysregulation can significantly modify the clinical outcomes of affected patients. In addition, the evidence suggests that IFN type I and III can play an important role in controlling viremia and modulating the immune response in COVID-19.

CONCLUSIONS

Due to their central role in immune response against SARS-CoV-2 infection, IFN type I and III could be considered for treatment of COVID-19.

摘要

背景

目前关于人类对 SARS-CoV-2 感染的免疫反应，以及在严重 COVID-19 病例中观察到的炎症反应加剧的信息有限。

目的

综述 I 型和 III 型干扰素在 SARS-CoV-2 感染中的作用的现有证据。

方法

我们综述了有关 SARS-CoV-2 感染免疫反应的现有已发表证据，以及关于 COVID-19 的特征和结局及其与 I 型和 III 型干扰素的关系的最新出版物。

结果

现有数据表明，免疫反应在控制 SARS-CoV-2 感染方面起着重要作用，免疫失调可显著改变受影响患者的临床结局。此外，有证据表明，IFN 型 I 和 III 可在控制病毒血症和调节 COVID-19 中的免疫反应方面发挥重要作用。

结论

由于它们在针对 SARS-CoV-2 感染的免疫反应中的核心作用，I 型和 III 型干扰素可考虑用于 COVID-19 的治疗。