Zimina Maria, Babich Olga, Prosekov Alexander, Sukhikh Stanislav, Ivanova Svetlana, Shevchenko Margarita, Noskova Svetlana
Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia.
Laboratory of Biocatalysis, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia.
Antibiotics (Basel). 2020 Aug 28;9(9):553. doi: 10.3390/antibiotics9090553.
This paper summarizes information about the division of bacteriocins into classes (Gram-negative bacteria, Gram-positive bacteria, and archaea). Methods for producing bacteriocins have been studied. It is known that bacteriocins, most successfully used today are products of secondary metabolism of lactic acid bacteria. It is established that the main method of bacteriocin research is PCR analysis, which makes it possible to quickly and easily identify the presence of bacteriocin encoding genes. The mechanism of cytotoxic action of bacteriocins has been studied. It is proved that the study of cytotoxic (antitumor) activity in laboratory conditions will lead to the clinical use of bacteriocins for cancer treatment in the near future. It is established that the incorporation of bacteriocins into nanoparticles and targeted delivery to areas of infection may soon become an effective treatment method. The delivery of bacteriocins in a concentrated form, such as encapsulated in nanoparticles, will increase their effectiveness and minimize potential toxic side effects. The analysis of publications on this topic confirmed that diverse research on bacteriocins is relevant.
本文总结了有关将细菌素分为几类的信息（革兰氏阴性菌、革兰氏阳性菌和古生菌）。已经研究了生产细菌素的方法。众所周知，当今最成功使用的细菌素是乳酸菌次级代谢的产物。已经确定，细菌素研究的主要方法是PCR分析，这使得能够快速、轻松地鉴定细菌素编码基因的存在。已经研究了细菌素的细胞毒性作用机制。事实证明，在实验室条件下对细胞毒性（抗肿瘤）活性的研究将在不久的将来导致细菌素在癌症治疗中的临床应用。已经确定，将细菌素掺入纳米颗粒并靶向递送至感染部位可能很快成为一种有效的治疗方法。以浓缩形式递送细菌素，例如封装在纳米颗粒中，将提高其有效性并使潜在的毒副作用最小化。对该主题出版物的分析证实，对细菌素的各种研究是相关的。
