Akpoghelie Patrick Othuke, Edo Great Iruoghene, Mafe Alice Njolke, Isoje Endurance Fegor, Igbuku Ufuoma Augustina, Ali Ali B M, Yousif Emad, Owheruo Joseph Oghenewogaga, Oberhiri Oberhiri Splendour, Essaghah Arthur Efeoghene Athan, Ahmed Dina S, Umar Huzaifa, Alamiery Ahmed A
Department of Food Science and Technology, Faculty of Science, Delta State University of Science and Technology, Ozoro, Delta State, Nigeria.
Department of Chemistry, Faculty of Science, Delta State University of Science and Technology, Ozoro, Delta State, Nigeria.
Probiotics Antimicrob Proteins. 2025 Apr 28. doi: 10.1007/s12602-025-10546-x.
Lactic acid bacteria (LAB) are Gram-positive cocci or rods that do not produce spores or respire. Their primary function is to ferment carbohydrates and produce lactic acid. The two primary forms of LAB that are currently recognized are homofermentative and heterofermentative. This review discusses the evolutionary diversity and the biochemical and biophysical conditions required by LAB for their metabolism. Next, it concentrates on the applications of these bacteria in gut health, cancer prevention, and overall well-being and food systems. There are numerous uses for LAB, including the food and dairy sectors, as probiotics to improve human and animal gut-health, as anti-carcinogenic agents, and in food safety as biopreservatives, pathogen inhibitors, and reducers of anti-nutrients in foods. The group included many genera, including Aerococcus, Carnobacterium, Enterococcus, Lactobacillus, Lactococcus, Leuconostoc, Streptococcus, Tetragenococcus, Vagococcus, and Weissella. Numerous species of Lactobacillus and Bifidobacterium genera as well as other microbes have been suggested as probiotic strains, or live microorganisms added to meals to improve health. LAB can colonize the intestine and take part in the host's physiological processes. This review briefly highlights the role of these bacteria in food safety and security as well as aspects of regulation and consumer acceptance. Finally, the recent innovations in LAB fermentations and the limitations and challenges of the applications of LAB in the food industry are discussed. Notwithstanding recent developments, the study of LAB and their functional components is still an emerging topic of study that has not yet realized its full potential.
乳酸菌(LAB)是革兰氏阳性球菌或杆菌,不产生孢子,也不进行呼吸作用。它们的主要功能是发酵碳水化合物并产生乳酸。目前公认的乳酸菌的两种主要形式是同型发酵和异型发酵。本综述讨论了乳酸菌代谢所需的进化多样性以及生化和生物物理条件。接下来,重点介绍了这些细菌在肠道健康、癌症预防、整体健康和食品系统中的应用。乳酸菌有许多用途,包括在食品和乳制品行业,作为改善人类和动物肠道健康的益生菌,作为抗癌剂,以及在食品安全方面作为生物防腐剂、病原体抑制剂和食品中抗营养物质的减少剂。该类群包括许多属,如气球菌属、肉食杆菌属、肠球菌属、乳杆菌属、乳球菌属、明串珠菌属、链球菌属、四联球菌属、漫游球菌属和魏斯氏菌属。许多乳杆菌属和双歧杆菌属的物种以及其他微生物已被建议作为益生菌菌株,即添加到膳食中以改善健康的活微生物。乳酸菌可以在肠道中定殖并参与宿主的生理过程。本综述简要强调了这些细菌在食品安全和保障方面的作用以及监管和消费者接受度方面的情况。最后,讨论了乳酸菌发酵的最新创新以及乳酸菌在食品工业应用中的局限性和挑战。尽管有最近的进展,但对乳酸菌及其功能成分的研究仍然是一个新兴的研究课题,尚未充分发挥其潜力。