Wijaya Christian J, Ismadji Suryadi, Aparamarta Hakun W, Gunawan Setiyo
Department of Chemical Engineering, Faculty of Industrial Technology, Institut Teknologi Sepuluh Nopember, Keputih Sukolilo, Surabaya 60111, Indonesia.
Department of Chemical Engineering, Widya Mandala Surabaya Catholic University, Kalijudan 37, Surabaya 60114, Indonesia.
ACS Omega. 2020 Aug 12;5(33):20967-20975. doi: 10.1021/acsomega.0c02425. eCollection 2020 Aug 25.
Because of their hydrophilic tendencies, the modification of cellulose nanocrystals (CNCs) is needed for applying them as a hydrophobic drug carrier. Previous studies have investigated several modification agents, such as cetyltrimethylammonium bromide. Natural surfactants, such as rarasaponins (RSs), are suitable to avoid human health and environmental issues. In this work, RSs were attached onto CNCs from bamboo shoots to enhance their hydrophobicity. The initial RS concentration and the operating temperature were studied to obtain the best conditions for the modification process, which had significances (-value < 5%) toward the amount of RSs linked on the CNCs () as the response. A as high as 203.81 ± 0.98 mg/g was obtained at an initial RS concentration of 2000 mg/L and an operating temperature of 30 °C. The curcumin uptake on CNCs-RSs reached 12.40 ± 0.24%, while it was slowly released until approximately 78% in 3 days.
由于其亲水性倾向，需要对纤维素纳米晶体（CNCs）进行改性，以便将其用作疏水性药物载体。先前的研究已经考察了几种改性剂，如十六烷基三甲基溴化铵。天然表面活性剂，如罗汉果皂苷（RSs），适合避免对人类健康和环境造成问题。在这项工作中，将罗汉果皂苷附着到竹笋来源的纤维素纳米晶体上，以增强其疏水性。研究了初始罗汉果皂苷浓度和操作温度，以获得改性过程的最佳条件，这对连接在纤维素纳米晶体上的罗汉果皂苷量（）具有显著影响（-值<5%），作为响应。在初始罗汉果皂苷浓度为2000 mg/L和操作温度为30℃时，获得了高达203.81±0.98 mg/g的。纤维素纳米晶体-罗汉果皂苷对姜黄素的摄取率达到12.40±0.24%，同时姜黄素缓慢释放，直到3天内约释放78%。
