Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, India.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Integral University, Lucknow, India.
Drug Res (Stuttg). 2020 Oct;70(10):448-454. doi: 10.1055/a-1224-3625. Epub 2020 Sep 2.
Myricetin is a member of the group of flavonoids called flavonols. Myricetin is obtained from various fruit, vegetables, tea, berries and red wine. Myricetin is characterized by the pysrogallol B-ring, and the more hydroxylated structure is known to be capable for its increased biological properties compared with other flavonols. Myricetin is produced by the Myricaceae, Anacardiaceae, Polygonaceae, Pinaceae and Primulacea families. It is soluble in organic solvent such as ethanol, DMSO (dimethyl sulfoxide), and dimethyl formamide (DMF). It is sparingly soluble in aqueous buffers. Myricetin shows its various pharmacological activities including antioxidant, anti-amyloidogenic, antibacterial, antiviral, antidiabetic, anticancer, anti-inflammatory, anti-epileptic and anti-ulcer. This review article focuses on pharmacological effects of Myricetin on different diseases such as osteoporotic disorder, anti-inflammatory disorder, alzheimer's disease, anti-epileptic, cancer, cardiac disorder, diabetic metabolic disorder, hepatoprotective disorder and gastro protective disorder.
杨梅素是黄酮类化合物中黄酮醇的一种。杨梅素存在于各种水果、蔬菜、茶、浆果和红酒中。杨梅素的特征在于具有邻苯三酚 B 环，而具有更多羟基化结构的杨梅素被认为具有比其他类黄酮更高的生物活性。杨梅素存在于杨梅科、漆树科、蓼科、松科和报春花科中。它可溶于有机溶剂，如乙醇、DMSO（二甲基亚砜）和 DMF（二甲基甲酰胺）。它在水性缓冲液中溶解度较低。杨梅素具有多种药理活性，包括抗氧化、抗淀粉样变性、抗菌、抗病毒、抗糖尿病、抗癌、抗炎、抗癫痫和抗溃疡。本文综述了杨梅素在骨质疏松症、炎症性疾病、阿尔茨海默病、抗癫痫、癌症、心脏疾病、糖尿病代谢紊乱、肝保护紊乱和胃保护紊乱等不同疾病中的药理作用。
