Department of Biochemistry, Era's Lucknow Medical College & Hospital, Era University, Lucknow, 226003, India.
Molecular Cell Biology Laboratory, Integral Information and Research Centre-4 (IIRC-4), Department of Bioengineering, Faculty of Engineering, Integral University, Lucknow, 226026, India.
Chin J Integr Med. 2024 Jan;30(1):75-84. doi: 10.1007/s11655-023-3701-5. Epub 2023 Jun 21.
Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, cancer, and other developmental defects over the last decade. Flavonoids are found abundantly in plant-derived foods such as fruits, vegetables, tea, cocoa, and wine. Fruits and vegetables contain phytochemicals like flavonoids, phenolics, alkaloids, saponins, and terpenoids. Flavonoids can act as anti-inflammatory, anti-allergic, anti-microbial (antibacterial, antifungal, and antiviral) antioxidant, anti-cancer, and anti-diarrheal agents. Flavonoids are also reported to upregulate apoptotic activity in several cancers such as hepatic, pancreatic, breast, esophageal, and colon. Myricetin is a flavonol which is naturally present in fruits and vegetables and has shown possible nutraceutical value. Myricetin has been portrayed as a potent nutraceutical that may protect against cancer. The focus of the present review is to present an updated account of studies demonstrating the anticancer potential of myricetin and the molecular mechanisms involved therein. A better understanding of the molecular mechanism(s) underlying its anticancer activity would eventually help in its development as a novel anticancer nutraceutical having minimal side effects.
良好的营养对于维持平衡的生活方式至关重要。在过去的十年中，营养的有益作用已被发现可以对抗营养失调，并且扩大了使用营养保健品来治疗和管理心血管疾病、癌症和其他发育缺陷。类黄酮在植物性食物中大量存在，如水果、蔬菜、茶、可可和酒。水果和蔬菜含有植物化学物质，如类黄酮、酚类、生物碱、皂苷和萜类。类黄酮可以作为抗炎、抗过敏、抗菌（抗细菌、抗真菌和抗病毒）、抗氧化、抗癌和抗腹泻剂。类黄酮还被报道可上调几种癌症（如肝、胰、乳、食管和结肠）中的细胞凋亡活性。杨梅素是一种类黄酮，天然存在于水果和蔬菜中，具有潜在的营养保健品价值。杨梅素已被描绘为一种有效的营养保健品，可能具有抗癌作用。本综述的重点是提供最新的研究，证明杨梅素的抗癌潜力及其涉及的分子机制。更好地了解其抗癌活性的分子机制（s）最终将有助于将其开发为一种新型的抗癌营养保健品，副作用最小。
