College of Chemistry, Green Catalysis Center, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, P.R. China.
Tetranov Biopharm, LLC, Zhengzhou 450052, P.R. China.
J Org Chem. 2020 Oct 2;85(19):12777-12784. doi: 10.1021/acs.joc.0c01672. Epub 2020 Sep 17.
A new and simple protocol for C8-H amination of 1-naphthylamine derivatives was developed using copper salt and di--butyl peroxide (DTBP) as the catalyst and oxidant, respectively. This reaction proceeded smoothly under the additive and solvent-free conditions. In addition, this amination showed excellent regioselectivity and could tolerate various functional groups.
开发了一种使用铜盐和过氧化二叔丁基（DTBP）分别作为催化剂和氧化剂的 1-萘胺衍生物 C8-H 胺化的新型简单方法。该反应在添加剂和无溶剂条件下顺利进行。此外，这种胺化反应具有出色的区域选择性，并且可以耐受各种官能团。
