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中枢神经系统结核与新冠疫情的相关性:神经学和治疗学的启示。

Correlation between CNS Tuberculosis and the COVID-19 Pandemic: The Neurological and Therapeutic Insights.

机构信息

Structural Biology & Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata 700032, India.

出版信息

ACS Chem Neurosci. 2020 Sep 16;11(18):2789-2792. doi: 10.1021/acschemneuro.0c00546. Epub 2020 Sep 3.

Abstract

The recent outbreak of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) from Wuhan, China, was caused by a single-stranded RNA virus which has kept the entire world stranded. The outbreak was first diagnosed with respiratory illness, but recent findings of acute necrotizing hemorrhage of brain, brain encephalopathy, and the presence of the virus in the cerebrospinal fluid (CSF) have unveiled its neuroinvasivness. Various clinical features related to the central nervous system (CNS) and peripheral nervous system (PNS) due to COVID-19 infection are now identified. We demonstrate here an apparent similarity in neurological disorders of COVID-19 with CNS tuberculosis, which suggests that some anti-tubercular drugs may be used as therapeutic agents against COVID-19 infection.

摘要

近期在中国武汉爆发的由单链 RNA 病毒引起的严重急性呼吸综合征冠状病毒 2 型(SARS-CoV-2),使全球陷入困境。该病毒最初被诊断为呼吸道疾病,但最近发现其具有神经侵袭性,表现为大脑急性坏死性出血、脑病,以及病毒存在于脑脊液(CSF)中。目前已经确定了与 COVID-19 感染相关的各种中枢神经系统(CNS)和周围神经系统(PNS)的临床特征。我们在这里证明,COVID-19 的神经紊乱与中枢神经系统结核具有明显的相似性,这表明一些抗结核药物可能被用作治疗 COVID-19 感染的药物。

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