IEEE J Biomed Health Inform. 2021 Jun;25(6):1926-1937. doi: 10.1109/JBHI.2020.3021532. Epub 2021 Jun 3.
We developed a wearable watch-based device to provide noninvasive, cuff-less blood pressure (BP) estimation in an at-home setting.
The watch measures single-lead electrocardiogram (ECG), tri-axial seismocardiogram (SCG), and multi-wavelength photoplethysmogram (PPG) signals to compute the pulse transit time (PTT), allowing for BP estimation. We sent our custom watch device and an oscillometric BP cuff home with 21 healthy subjects, and captured the natural variability in BP over the course of a 24-hour period.
After calibration, our Pearson correlation coefficient (PCC) of 0.69 and root-mean-square-error (RMSE) of 2.72 mmHg suggest that noninvasive PTT measurements correlate with around-the-clock BP. Using a novel two-point calibration method, we achieved a RMSE of 3.86 mmHg. We further demonstrated the potential of a semi-globalized adaptive model to reduce calibration requirements.
This is, to the best of our knowledge, the first time that BP has been comprehensively estimated noninvasively using PTT in an at-home setting. We showed a more convenient method for obtaining ambulatory BP than through the use of the standard oscillometric cuff. We presented new calibration methods for BP estimation using fewer calibration points that are more practical for a real-world scenario.
A custom watch (SeismoWatch) capable of taking multiple BP measurements enables reliable remote monitoring of daily BP and paves the way towards convenient hypertension screening and management, which can potentially reduce hospitalizations and improve quality of life.
我们开发了一种可穿戴的手表式设备，以便在家庭环境中提供非侵入性、无袖带的血压（BP）估计。
该手表测量单导联心电图（ECG）、三轴地震心动图（SCG）和多波长光体积描记图（PPG）信号，以计算脉搏传输时间（PTT），从而进行血压估计。我们向 21 名健康受试者发送了我们的定制手表设备和一个振荡血压袖带，并在 24 小时内捕捉到了血压的自然变化。
经过校准，我们的皮尔逊相关系数（PCC）为 0.69，均方根误差（RMSE）为 2.72mmHg，表明非侵入性 PTT 测量与 24 小时内的血压相关。使用一种新的两点校准方法，我们实现了 3.86mmHg 的 RMSE。我们进一步证明了半全局自适应模型的潜力，可以降低校准要求。
据我们所知，这是第一次在家庭环境中使用 PTT 全面无创地估计血压。我们展示了一种比使用标准振荡血压袖带更方便的获取动态血压的方法。我们提出了使用更少校准点进行血压估计的新校准方法，更适合实际情况。
一款能够进行多次血压测量的定制手表（SeismoWatch）能够可靠地远程监测日常血压，为方便的高血压筛查和管理铺平了道路，这可能会减少住院治疗并提高生活质量。
