Alvarez J F, Varela I, Ruiz-Albusac J M, Mato J M
Fundacion Jimenez Diaz, Madrid, Spain.
Biochem Biophys Res Commun. 1988 May 16;152(3):1455-62. doi: 10.1016/s0006-291x(88)80449-2.
A phosphatidylinositol-glycan has been implicated in the mechanism of action of insulin. Some of the actions of insulin may be mediated by the generation of the polar head group of this phosphatidylinositol-glycan. Localisation of the insulin-sensitive phosphatidylinositol-glycan was investigated by reacting the glycophospholipid with the imidoester [1-14C]-isethionyl acetimidate. The present results indicate that most of the insulin-sensitive phosphatidylinositol-glycan is localized at the plasma membrane of rat liver, being 85% of the glycophospholipid present at the outer surface of the cell. These results suggest a paracrine action of insulin.
一种磷脂酰肌醇聚糖与胰岛素的作用机制有关。胰岛素的某些作用可能是由这种磷脂酰肌醇聚糖的极性头部基团的生成介导的。通过使糖磷脂与亚胺酯[1-¹⁴C] -异硫代乙酰亚胺反应，研究了胰岛素敏感的磷脂酰肌醇聚糖的定位。目前的结果表明，大多数胰岛素敏感的磷脂酰肌醇聚糖位于大鼠肝脏的质膜上，占细胞外表面存在的糖磷脂的85%。这些结果提示胰岛素具有旁分泌作用。
