模拟胰岛素作用的磷酸寡糖在分离的大鼠肝细胞中的转运。肾上腺切除术和糖皮质激素治疗的影响。
Transport in isolated rat hepatocytes of the phospho-oligosaccharide that mimics insulin action. Effects of adrenalectomy and glucocorticoid treatment.
作者信息
Alvarez J F, Sánchez-Arias J A, Guadaño A, Estévez F, Varela I, Felíu J E, Mato J M
机构信息
Instituto de Investigaciones Biomédicas, C.S.I.C., Madrid, Spain.
出版信息
Biochem J. 1991 Mar 1;274 ( Pt 2)(Pt 2):369-74. doi: 10.1042/bj2740369.
Abstract
The addition to intact cells of an inositol phospho-oligosaccharide (POS), which is the polar head-group of an insulin-sensitive glycosylphosphatidylinositol, mimics and may mediate some of the biological effects of this hormone. Here we report the existence of a POS transport system in hepatocytes. This POS transport system is specific and time- and dose-dependent. Insulin-resistance caused by dexamethasone administration to rats was accompanied by a decrease in the hepatocyte POS transport system. In contrast, bilateral adrenalectomy provoked a significant increase in the transport of POS. Both the temporal uptake of POS and the regulation of this process by conditions known to modify the sensitivity to insulin suggest that this novel transport system might be involved in the insulin signalling mechanism.
摘要
向完整细胞中添加肌醇磷酸寡糖（POS），它是胰岛素敏感糖基磷脂酰肌醇的极性头部基团，可模拟并可能介导该激素的一些生物学效应。在此我们报告肝细胞中存在一种POS转运系统。该POS转运系统具有特异性，且具有时间和剂量依赖性。给大鼠注射地塞米松导致的胰岛素抵抗伴随着肝细胞POS转运系统的降低。相反，双侧肾上腺切除引起POS转运显著增加。POS的瞬时摄取以及已知可改变胰岛素敏感性的条件对这一过程的调节表明，这种新型转运系统可能参与胰岛素信号传导机制。
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本文引用的文献
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