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1
Transport in isolated rat hepatocytes of the phospho-oligosaccharide that mimics insulin action. Effects of adrenalectomy and glucocorticoid treatment.模拟胰岛素作用的磷酸寡糖在分离的大鼠肝细胞中的转运。肾上腺切除术和糖皮质激素治疗的影响。
Biochem J. 1991 Mar 1;274 ( Pt 2)(Pt 2):369-74. doi: 10.1042/bj2740369.
2
Insulin-induced phospho-oligosaccharide stimulates amino acid transport in isolated rat hepatocytes.胰岛素诱导的磷酸寡糖刺激分离的大鼠肝细胞中的氨基酸转运。
Biochem J. 1990 Apr 15;267(2):541-4. doi: 10.1042/bj2670541.
3
Effect of adrenalectomy and glucocorticoid treatment on the levels of an insulin-sensitive glycosyl-phosphatidylinositol in isolated rat hepatocytes.肾上腺切除术和糖皮质激素治疗对分离的大鼠肝细胞中胰岛素敏感性糖基磷脂酰肌醇水平的影响。
Mol Cell Endocrinol. 1990 Jan 2;68(1):R1-5. doi: 10.1016/0303-7207(90)90173-6.
4
A phospho-oligosaccharide mimics insulin action on glycogen phosphorylase and pyruvate kinase activities in isolated rat hepatocytes.一种磷酸化寡糖可模拟胰岛素对分离的大鼠肝细胞中糖原磷酸化酶和丙酮酸激酶活性的作用。
Biochem Biophys Res Commun. 1987 Sep 15;147(2):765-71. doi: 10.1016/0006-291x(87)90996-x.
5
Inositol phospho-oligosaccharides from rat fibroblasts and adipocytes stimulate 3-O-methylglucose transport.来自大鼠成纤维细胞和脂肪细胞的肌醇磷酸寡糖刺激3 - O - 甲基葡萄糖转运。
Biochem J. 1993 Nov 1;295 ( Pt 3)(Pt 3):699-704. doi: 10.1042/bj2950699.
6
Adrenalectomy decreases amino-acid transport in hepatocytes.肾上腺切除术会降低肝细胞中的氨基酸转运。
Mol Cell Endocrinol. 1981 Dec;24(3):315-23. doi: 10.1016/0303-7207(81)90006-x.
7
Asymmetric distribution of the phosphatidylinositol-linked phospho-oligosaccharide that mimics insulin action in the plasma membrane.模仿胰岛素在质膜中作用的磷脂酰肌醇连接的磷酸寡糖的不对称分布。
Eur J Biochem. 1990 Mar 10;188(2):213-8. doi: 10.1111/j.1432-1033.1990.tb15392.x.
8
Mannose, glucosamine and inositol monophosphate inhibit the effects of insulin on lipogenesis. Further evidence for a role for inositol phosphate-oligosaccharides in insulin action.甘露糖、氨基葡萄糖和肌醇单磷酸可抑制胰岛素对脂肪生成的作用。磷酸肌醇寡糖在胰岛素作用中发挥作用的进一步证据。
Biochem J. 1990 Mar 15;266(3):909-16.
9
Inositol phospho-oligosaccharide stimulates cell proliferation in the early developing inner ear.肌醇磷酸寡糖刺激内耳早期发育过程中的细胞增殖。
Dev Biol. 1991 Feb;143(2):432-5. doi: 10.1016/0012-1606(91)90095-k.
10
Regulation of insulin binding and glycogenesis by insulin and dexamethasone in cultured rat hepatocytes.胰岛素和地塞米松对培养大鼠肝细胞中胰岛素结合及糖原生成的调节作用
Biochim Biophys Acta. 1985 Dec 12;847(3):352-61. doi: 10.1016/0167-4889(85)90041-2.

引用本文的文献

1
The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases.肌醇的生物医学用途：一种针对衰老和神经退行性疾病中代谢功能障碍的营养补充剂方法。
Biomedicines. 2020 Aug 20;8(9):295. doi: 10.3390/biomedicines8090295.
2
Insulin-mimicking bioactivities of acylated inositol glycans in several mouse models of diabetes with or without obesity.酰化肌醇聚糖在几种有或无肥胖症的糖尿病小鼠模型中的胰岛素模拟生物活性。
PLoS One. 2014 Jun 27;9(6):e100466. doi: 10.1371/journal.pone.0100466. eCollection 2014.
3
D-chiro-inositol glycan stimulates insulin secretion in pancreatic β cells.D-手性肌醇聚糖刺激胰腺β细胞分泌胰岛素。
Mol Cell Endocrinol. 2014 Apr 25;387(1-2):1-7. doi: 10.1016/j.mce.2014.02.004. Epub 2014 Feb 14.
4
D-chiro-inositol glycans in insulin signaling and insulin resistance.D-手性肌醇聚糖在胰岛素信号和胰岛素抵抗中的作用。
Mol Med. 2010 Nov-Dec;16(11-12):543-52. doi: 10.2119/molmed.2010.00107. Epub 2010 Aug 27.
5
The biological activity of structurally defined inositol glycans.结构明确的肌醇聚糖的生物活性。
Future Med Chem. 2009 Apr;1(1):95-118. doi: 10.4155/fmc.09.6.
6
Uncoupling between insulin and release of a D-chiro-inositol-containing inositolphosphoglycan mediator of insulin action in obese women With polycystic ovary syndrome.肥胖伴多囊卵巢综合征妇女的胰岛素作用的 D-手性肌醇含有的肌醇磷酸聚糖介质与胰岛素释放的解偶联。
Metab Syndr Relat Disord. 2010 Apr;8(2):127-36. doi: 10.1089/met.2009.0052.
7
ACTH stimulates the release of alkaline phosphatase through Gi-mediated activation of a phospholipase C and the release of inositol-phosphoglycan.促肾上腺皮质激素（ACTH）通过Gi介导的磷脂酶C激活和肌醇磷酸聚糖的释放来刺激碱性磷酸酶的释放。
Mol Cell Biochem. 2004 Mar;258(1-2):191-9. doi: 10.1023/b:mcbi.0000012855.94291.dd.
8
Glycosylphosphatidylinositol (GPI) hydrolysis by transforming growth factor-beta1 (TGF-beta1) as a potential early step in the inhibition of epithelial cell proliferation.转化生长因子-β1（TGF-β1）介导的糖基磷脂酰肌醇（GPI）水解可能是抑制上皮细胞增殖的早期潜在步骤。
Mol Cell Biochem. 2000 May;208(1-2):143-50. doi: 10.1023/a:1007064211120.

本文引用的文献

1
Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action.皮质醇诱导的人体胰岛素抵抗：由于胰岛素作用的受体后缺陷，导致葡萄糖生成的抑制受损和葡萄糖利用的刺激受损。
J Clin Endocrinol Metab. 1982 Jan;54(1):131-8. doi: 10.1210/jcem-54-1-131.
2
Glycosphingolipids in cellular interaction, differentiation, and oncogenesis.细胞相互作用、分化及肿瘤发生过程中的糖鞘脂
Annu Rev Biochem. 1981;50:733-64. doi: 10.1146/annurev.bi.50.070181.003505.
3
Stimulatory effect of vasoactive intestinal peptide on glycogenolysis and gluconeogenesis in isolated rat hepatocytes: antagonism by insulin.血管活性肠肽对离体大鼠肝细胞糖原分解和糖异生的刺激作用：胰岛素的拮抗作用。
Endocrinology. 1983 Jun;112(6):2120-7. doi: 10.1210/endo-112-6-2120.
4
Topographical distribution of complex carbohydrates in the erythrocyte membrane.红细胞膜中复合碳水化合物的拓扑分布。
J Biol Chem. 1974 Apr 10;249(7):2135-42.
5
Trypanosoma brucei variant surface glycoprotein has a sn-1,2-dimyristyl glycerol membrane anchor at its COOH terminus.布氏锥虫可变表面糖蛋白在其羧基末端有一个sn-1,2-二肉豆蔻酰甘油膜锚定物。
J Biol Chem. 1985 Apr 25;260(8):4963-8.
6
Identification of a novel insulin-sensitive glycophospholipid from H35 hepatoma cells.从H35肝癌细胞中鉴定出一种新型胰岛素敏感性糖磷脂。
J Biol Chem. 1987 Feb 15;262(5):2131-7.
7
The polar head group of a novel insulin-sensitive glycophospholipid mimics insulin action on phospholipid methyltransferase.一种新型胰岛素敏感性糖磷脂的极性头部基团模拟胰岛素对磷脂甲基转移酶的作用。
FEBS Lett. 1986 Dec 15;209(2):238-42. doi: 10.1016/0014-5793(86)81119-x.
8
Inhibition of cyclic AMP-dependent protein kinase by the polar head group of an insulin-sensitive glycophospholipid.胰岛素敏感糖磷脂的极性头部基团对环磷酸腺苷依赖性蛋白激酶的抑制作用。
Biochim Biophys Acta. 1988 Jan 18;968(1):69-76. doi: 10.1016/0167-4889(88)90045-6.
9
Inositol glycan mimics the action of insulin on glucose utilization in rat adipocytes.肌醇聚糖可模拟胰岛素对大鼠脂肪细胞葡萄糖利用的作用。
Biochem Biophys Res Commun. 1987 Dec 31;149(3):1084-92. doi: 10.1016/0006-291x(87)90519-5.
10
Phospho-dephospho-control by insulin is mimicked by a phospho-oligosaccharide in adipocytes.脂肪细胞中的一种磷酸化寡糖可模拟胰岛素的磷酸化-去磷酸化调控。
Nature. 1987;330(6143):77-9. doi: 10.1038/330077a0.

模拟胰岛素作用的磷酸寡糖在分离的大鼠肝细胞中的转运。肾上腺切除术和糖皮质激素治疗的影响。

Transport in isolated rat hepatocytes of the phospho-oligosaccharide that mimics insulin action. Effects of adrenalectomy and glucocorticoid treatment.

作者信息

Alvarez J F, Sánchez-Arias J A, Guadaño A, Estévez F, Varela I, Felíu J E, Mato J M

机构信息

Instituto de Investigaciones Biomédicas, C.S.I.C., Madrid, Spain.

出版信息

Biochem J. 1991 Mar 1;274 ( Pt 2)(Pt 2):369-74. doi: 10.1042/bj2740369.

DOI:10.1042/bj2740369
PMID:2006906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1150146/
Abstract

The addition to intact cells of an inositol phospho-oligosaccharide (POS), which is the polar head-group of an insulin-sensitive glycosylphosphatidylinositol, mimics and may mediate some of the biological effects of this hormone. Here we report the existence of a POS transport system in hepatocytes. This POS transport system is specific and time- and dose-dependent. Insulin-resistance caused by dexamethasone administration to rats was accompanied by a decrease in the hepatocyte POS transport system. In contrast, bilateral adrenalectomy provoked a significant increase in the transport of POS. Both the temporal uptake of POS and the regulation of this process by conditions known to modify the sensitivity to insulin suggest that this novel transport system might be involved in the insulin signalling mechanism.

摘要

向完整细胞中添加肌醇磷酸寡糖（POS），它是胰岛素敏感糖基磷脂酰肌醇的极性头部基团，可模拟并可能介导该激素的一些生物学效应。在此我们报告肝细胞中存在一种POS转运系统。该POS转运系统具有特异性，且具有时间和剂量依赖性。给大鼠注射地塞米松导致的胰岛素抵抗伴随着肝细胞POS转运系统的降低。相反，双侧肾上腺切除引起POS转运显著增加。POS的瞬时摄取以及已知可改变胰岛素敏感性的条件对这一过程的调节表明，这种新型转运系统可能参与胰岛素信号传导机制。