Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR 97006, USA.
Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR 97123, USA.
Biotechniques. 2020 Nov;69(5):392-399. doi: 10.2144/btn-2020-0069. Epub 2020 Sep 4.
The use of contrast agents as signal enhancers during ultrasound improves visualization and the diagnostic utility of this technology in medical imaging. Although widely used in many disciplines, contrast ultrasound is not routinely implemented in obstetrics, largely due to safety concerns of administered agents for pregnant women and the limited number of studies that address this issue. Here the microbubble characteristics that make them beneficial for enhancement of the blood pool and the quantification of real-time imaging are reviewed. Literature from pregnant animal model studies and safety assessments are detailed, and the potential for contrast-enhanced ultrasound to provide clinically relevant data and benefit our understanding of early placental development and detection of placental dysfunction is discussed.
在超声检查中使用对比剂作为信号增强剂可以提高该技术在医学成像中的可视化效果和诊断效用。尽管对比超声在许多学科中得到广泛应用，但在妇产科中并未常规实施，这主要是由于对孕妇使用的给药对比剂的安全性顾虑以及针对该问题的研究数量有限。本文综述了使微泡有益于增强血池和实时成像定量的特性。详细介绍了来自妊娠动物模型研究和安全性评估的文献，并讨论了对比增强超声提供临床相关数据的潜力及其对早期胎盘发育和胎盘功能障碍检测的益处。
