School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Huangpu District, Shanghai, 200025, China.
School of International and Public Affairs, Shanghai Jiao Tong University, Shanghai, China.
Respir Res. 2020 Sep 3;21(1):230. doi: 10.1186/s12931-020-01497-8.
Early life exposure in the uterus had a long-term effect on children's health. As the prevalence of allergies is increasing with a remarkable sex difference, very few studies have traced back to their early origins. We sought to investigate if maternal behavioral exposure, herein sleep, physical activity, and screen time during pregnancy is associated with childhood respiratory allergies. The sex difference would be examined.
Six thousand two hundred thirty-six mother-child pairs from Shanghai Children Allergy Study (SCAS) were enrolled, The International Study of Asthma and Allergies in Childhood questionnaire was adopted to evaluate respiratory allergic diseases.
14.6, 16.2, and 21.0% of children had asthma, wheeze, and allergic rhinitis, respectively. Maternal short sleep duration, lack of physical activity, and too much screen exposure during pregnancy could increase the risk of childhood respiratory allergies, however, the significance was found only in males. Moreover, a dose-response trend was clearly shown, any two of the three combined could increase the risk (OR,1.921; 95% CI,1.217-3.033), and the coexistence of all three further amplified the risk (OR,2.412; 95% CI,1.489-3.906). The findings can be verified in allergen test subgroup and each single type of respiratory allergies in most cases.
Maternal unhealthy behaviors during pregnancy could increase the risk of childhood respiratory allergies with a dose-response pattern. Males were more susceptible to the association. The identification of modifiable maternal risk behaviors lies in the emphasis of intervention in early life to face up increasing childhood allergies.
子宫内的早期暴露对儿童健康有长期影响。由于过敏的患病率呈显著性别差异且不断增加，很少有研究追溯到其早期起源。我们试图调查母亲在怀孕期间的行为暴露（包括睡眠、体力活动和屏幕时间）是否与儿童呼吸道过敏有关。我们将检查性别差异。
我们纳入了 6236 对来自上海儿童过敏研究（SCAS）的母子对。采用国际儿童哮喘和过敏研究问卷评估呼吸道过敏疾病。
分别有 14.6%、16.2%和 21.0%的儿童患有哮喘、喘息和过敏性鼻炎。母亲在怀孕期间睡眠不足、缺乏体力活动和过多的屏幕暴露会增加儿童呼吸道过敏的风险，但这种关联仅在男性中具有统计学意义。此外，还存在明显的剂量反应趋势，任何两种行为的结合都会增加风险（OR，1.921；95%CI，1.217-3.033），三种行为并存会进一步放大风险（OR，2.412；95%CI，1.489-3.906）。在过敏原测试亚组和大多数情况下的每种单一类型的呼吸道过敏中，都可以验证这些发现。
母亲在怀孕期间的不健康行为会增加儿童呼吸道过敏的风险，且存在剂量反应模式。男性更容易受到这种关联的影响。确定可改变的母亲风险行为在于强调在生命早期进行干预，以应对儿童过敏症的不断增加。
