从海水中分离出的OUS9菌株的生物活性化合物的伤口愈合活性。

Shanthi Kumari K, Shivakrishna Pabba, Ganduri V S Ramakrishna

Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur 522502, A.P., India.

Department of Microbiology, Osmania University, Hyderabad 500 007, Telangana, India.

Saudi J Biol Sci. 2020 Sep;27(9):2398-2402. doi: 10.1016/j.sjbs.2020.05.007. Epub 2020 May 11.

Marine species are increasingly important as a source of specific biological active metabolites. Marine species comprise almost half of global biodiversity. Oceans and sea are thus the biggest source of positive natural compounds that could be utilized in the pharmaceutical industry as functional constituents. In the present study was to find out the wound healing property of the bioactive compounds from . OUS9 isolated from marine source. The in vivo wound healing activity was studied using excision wound model. The KLUF 10 and KLUF13 ointment was prepared and used to determine wound healing activity in albino rats. Topical application of the ointment enhanced the contraction of wound in contrast with rat control group. KLUF13 had shown strong healing ability in wounds and had a positive influence on the various phases of wound repair.

海洋物种作为特定生物活性代谢物的来源正变得越来越重要。海洋物种几乎占全球生物多样性的一半。因此，海洋是可在制药工业中用作功能成分的天然阳性化合物的最大来源。在本研究中，旨在找出从海洋来源分离的OUS9中生物活性化合物的伤口愈合特性。使用切除伤口模型研究体内伤口愈合活性。制备了KLUF 10和KLUF13软膏，并用于确定白化大鼠的伤口愈合活性。与大鼠对照组相比，局部应用该软膏可增强伤口收缩。KLUF13在伤口愈合方面显示出强大的能力，并对伤口修复的各个阶段产生积极影响。