Sabidi Sarah, Koh Soo Peng, Abd Shukor Shazwan, Adzni Sharifudin Shaiful, Sew Yun Shin
Food Science and Technology Research Centre MARDI Headquarters Persiaran MARDI-UPM Serdang Malaysia.
Biotechnology & Nanotechnology Research Centre MARDI Headquarters Persiaran MARDI-UPM Serdang Malaysia.
Food Sci Nutr. 2020 Jul 1;8(8):4370-4378. doi: 10.1002/fsn3.1734. eCollection 2020 Aug.
Fermented jackfruit () extracts were produced using pure symbiotic culture of bacteria and yeast (SCOBY) under controlled fermentation process. Both female and male Sprague-Dawley rats were orally administrated with 4,000 mg/kg of fermented jackfruit pulp and leaves extracts for 28 consecutive days. Body weight of rats was recorded at 1-week interval until necropsy day. There was no mortality reported along the experiment with no significant differences ( > .05) record among organ histopathology and blood biochemical parameters in treated groups when compared to control group. Interestingly, there were significant differences ( < .05) in the lower body weight gained of treated rats groups as opposed to control group, indicating the potential anti-obesity effect of fermented jackfruit extracts. In conclusion, no toxicity symptoms were observed in 28 days oral administration toxicity study of fermented jackfruit pulp and leaves extracts in Sprague-Dawley rats for both sexes.
发酵波罗蜜（）提取物是在受控发酵过程中使用细菌和酵母的纯共生培养物（SCOBY）生产的。将雌性和雄性斯普拉格-道利大鼠连续28天口服给予4000毫克/千克的发酵波罗蜜果肉和叶提取物。每隔1周记录大鼠体重，直至尸检日。实验期间未报告死亡情况，与对照组相比，治疗组的器官组织病理学和血液生化参数无显著差异（>0.05）。有趣的是，与对照组相比，治疗大鼠组的体重增加较低存在显著差异（<0.05），表明发酵波罗蜜提取物具有潜在的抗肥胖作用。总之，在对雌雄斯普拉格-道利大鼠进行的发酵波罗蜜果肉和叶提取物28天口服给药毒性研究中，未观察到毒性症状。
