Sharifan Payam, Khoshakhlagh Mahdieh, Khorasanchi Zahra, Darroudi Susan, Rezaie Mitra, Safarian Mohammad, Vatanparast Hassan, Afshari Asma, Ferns Gordon, Ghazizadeh Hamideh, Ghayour Mobarhan Majid
Department of Nutrition School of Medicine Mashhad University of Medical Sciences Mashhad Iran.
Department of Medical Biochemistry Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.
Food Sci Nutr. 2020 Jul 6;8(8):4484-4490. doi: 10.1002/fsn3.1750. eCollection 2020 Aug.
Sleep disorders are a common condition globally. Vitamin D receptors are present on cells in several regions of the brain. It is possible that vitamin D status may affect brain function, including sleep patterns. We aimed to evaluate the 1,500 IU of Nano-encapsulated vitamin D fortified in dairy products on the symptoms of insomnia and associated improvement of quality of life.
A case series was undertaken as part of the project. Subjects enrolled among adults with abdominal obesity. Twenty-nine subjects with insomnia were selected according to the results of Insomnia Severity Index questionnaire and quality of life using a Short Form Health Survey (SF-36) questionnaire. Subjects were allocated to four groups: low-fat milk fortified by 1,500 IU vitamin D ( = 8), simple milk ( = 8), low-fat yogurt fortified by 1,500 IU vitamin D ( = 7), and simple yogurt ( = 6) and were treated for 10 weeks.
The insomnia score improved after the intervention in the group receiving vitamin D fortified milk compared to group receiving unfortified milk ( < .001). There were no significant differences between the two groups taking yogurt (fortified vs. unfortified). Comparison of quality of life scores between baseline and after intervention indicated significant improvements in both fortified and simple milk groups ( = .002 and = .03, respectively); but no differences were found in the groups taking yogurt.
Fortified low-fat milk containing 1,500 IU vitamin D can improve insomnia symptoms and subsequently quality of life.Trial registration number: IRCT20101130005280N27, www.IRCT.ir.
睡眠障碍在全球范围内是一种常见病症。维生素D受体存在于大脑多个区域的细胞上。维生素D状态可能会影响大脑功能，包括睡眠模式。我们旨在评估乳制品中强化的1500国际单位纳米包裹维生素D对失眠症状及生活质量相关改善情况的影响。
作为该项目的一部分，开展了一项病例系列研究。研究对象为腹部肥胖的成年人。根据失眠严重程度指数问卷结果和使用简短健康调查问卷（SF - 36）的生活质量情况，选取了29名失眠患者。将研究对象分为四组：添加1500国际单位维生素D的低脂牛奶组（n = 8）、纯牛奶组（n = 8）、添加1500国际单位维生素D的低脂酸奶组（n = 7）和纯酸奶组（n = 6），并进行为期10周的治疗。
与未强化牛奶组相比，接受维生素D强化牛奶组干预后失眠评分有所改善（P <.001）。两组酸奶组（强化与未强化）之间无显著差异。基线与干预后生活质量评分比较表明，强化牛奶组和纯牛奶组均有显著改善（分别为P =.002和P =.03）；但酸奶组未发现差异。
含有1500国际单位维生素D的强化低脂牛奶可改善失眠症状，进而提高生活质量。试验注册号：IRCT20101130005280N27，www.IRCT.ir 。
