Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Med Res Opin. 2021 Apr;37(4):579-588. doi: 10.1080/03007995.2021.1874324. Epub 2021 Mar 8.
BACKGROUND & AIMS: Vitamin D deficiency is widespread worldwide. In this study, we aimed to evaluate the effect of a nano encapsulated form of vitamin D used for fortifying low-fat dairy products (milk and yogurt) on anthropometric indices, glycemic status, and lipid profile in subjects with abdominal obesity.
In a totally (quadruple) blinded, randomized, and parallel-controlled trial, 306 individuals with abdominal obesity were randomly allocated to one of four groups: fortified low-fat yogurt (FY, 1500 IU nano encapsulated vitamin D per 150 g/d), non-fortified low-fat yogurt (nFY), fortified low-fat milk (FM, 1500 IU nano encapsulated vitamin D per 200 g/d), non-fortified low-fat milk (nFM), for 10 weeks (nFM and nFY, were considered as the control groups). Anthropometric and biochemical parameters were measured at baseline and after a ten-week trial in Mashhad, Iran.
After the ten-week intervention, we found a significant increase in serum concentration of 25(OH)D in both the FM and FY groups compared to the respective control groups (19.10 ± 5.69 ng/mL and 20.88 ± 5.76 ng/mL respectively, < .001). We observed a significant reduction in weight to hip ratio ( = .04) and a significant improvement in triglyceride ( < .001) and HDL-C ( = .01) only in FM group compared to nFM group. Also, we found a significant reduction in fasting serum insulin ( < .001), and a significant improvement of HOMA-IR ( < .001) and QUICKI ( < .001) in both intervention groups compared to their placebos.
An intake of fortified dairy products containing nano-encapsulated vitamin D was associated with an improvement in some measures of anthropometric indices, glucose homeostasis, and lipid profiles, particularly in individuals receiving fortified milk. Hence, along with other benefits, fortification of dairy products with vitamin D may be an effective approach to improve some cardiometabolic indicators, such as insulin resistance.
IRCT20101130005280N27.
维生素 D 缺乏在全球范围内普遍存在。本研究旨在评估用于强化低脂乳制品（牛奶和酸奶）的纳米封装形式的维生素 D 对腹型肥胖者的人体测量指数、血糖状态和血脂谱的影响。
在一项完全（四重）盲、随机、平行对照试验中，306 名腹型肥胖者被随机分配到以下 4 组中的一组：强化低脂酸奶（FY，每 150g/d 含 1500IU 纳米封装维生素 D）、非强化低脂酸奶（nFY）、强化低脂牛奶（FM，每 200g/d 含 1500IU 纳米封装维生素 D）、非强化低脂牛奶（nFM），干预时间为 10 周（nFM 和 nFY 被视为对照组）。在伊朗马什哈德测量基线和 10 周试验后的人体测量学和生化参数。
干预 10 周后，与相应的对照组相比，FM 和 FY 组血清 25（OH）D 浓度均显著升高（分别为 19.10±5.69ng/mL 和 20.88±5.76ng/mL，均<0.001）。与 nFM 组相比，FM 组体重与臀围比显著降低（ = 0.04），三酰甘油显著降低（ < 0.001），高密度脂蛋白胆固醇显著升高（ = 0.01）。此外，与安慰剂组相比，两组干预组空腹血清胰岛素均显著降低（ < 0.001），HOMA-IR（ < 0.001）和 QUICKI（ < 0.001）均显著改善。
摄入含纳米封装维生素 D 的强化乳制品与人体测量指数、血糖稳态和血脂谱的某些指标改善有关，尤其是在接受强化牛奶的个体中。因此，除了其他益处外，用维生素 D 强化乳制品可能是改善胰岛素抵抗等一些心血管代谢指标的有效方法。
IRCT20101130005280N27。
