Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute for Infection & Immunity, Melbourne, Australia.
PLoS Negl Trop Dis. 2020 Sep 4;14(9):e0008501. doi: 10.1371/journal.pntd.0008501. eCollection 2020 Sep.
Buruli ulcer (BU) is an emerging ulcerative skin disease caused by infection with Mycobacterium ulcerans. Efforts to control its spread have been hampered by our limited understanding of M. ulcerans reservoirs and transmission, and the factors leading to the emergence of BU disease in a particular region. In this report we investigate an anecdotal link between damming the Mapé River in Cameroon and the emergence of BU in the Health Districts bordering Lake Bankim, the impoundment created by the Mapé dam. We used bacterial population genomics and molecular dating to find compelling support for a 2000 M. ulcerans introduction event that followed about 10 years after the filling of the newly created impoundment in 1988. We compared the genomic reconstructions with high-resolution satellite imagery to investigate what major environmental alterations might have driven the emergence of the new focus.
布鲁里溃疡（BU）是一种新出现的溃疡性皮肤疾病，由溃疡分枝杆菌感染引起。由于我们对溃疡分枝杆菌的储存库和传播方式以及导致特定地区出现 BU 疾病的因素了解有限，因此控制其传播的努力受到了阻碍。在本报告中，我们调查了喀麦隆马普河筑坝与 BU 在马普大坝形成的班基姆湖（Lake Bankim）接壤的卫生区出现之间的传闻联系。我们使用细菌种群基因组学和分子定年来寻找有力的证据支持 2000 年溃疡分枝杆菌传入事件，该事件发生在 1988 年新形成的水库蓄水大约 10 年后。我们将基因组重建与高分辨率卫星图像进行了比较，以调查哪些重大的环境变化可能导致了新发病灶的出现。
